Publikationen

2024

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

Popović L, Wintgens J P, Wu Y, Brankatschk B, Menninger S, Degenhart C, Jensen N, Wichert S P, Klebl B, Rossner M J and Wehr M C. iScience. 2024; doi: 10.1016/j.isci.2024.108839

Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland

Bjornstad F, Havik S, Aarhus T I, Mahdi I, Unger A, Habenberger P, Degenhart C, Eickhoff J, Klebl B M, Sundby E and Hoff B H. Eur J Med Chem. 2024; 265 116053. doi: 10.1016/j.ejmech.2023.116053

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

Teuber A, Schulz T, Fletcher B S, Gontla R, Muhlenberg T, Zischinsky M L, Niggenaber J, Weisner J, Kleinbolting S B, Lategahn J, Sievers S, Muller M P, Bauer S and Rauh D. Nat Commun. 2024; 15 (1): 63. doi: 10.1038/s41467-023-44376-8

2020

Small-molecule Inhibitors of Human Mitochondrial DNA Transcription

Bonekamp N A, Peter B, Hillen H S, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel M S, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson C M, Larsson N G. Nature. 2020; 588 (7839): 712-716. doi: 10.1038/s41586-020-03048-z

TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics

Kunig V B K, Potowski M, Akbarzadeh M, Klika Skopic M, Dos Santos Smith D, Arendt L, Dormuth I, Adihou H, Andlovic B, Karatas H, Shaabani S, Zarganes-Tzitzikas T, Neochoritis C G, Zhang R, Groves M, Gueret S M, Ottmann C, Rahnenfuhrer J, Fried R, Domling A, Brunschweiger A. Angew Chem Int Ed Engl. 2020; 59 (46): 20338-20342. doi: 10.1002/anie.202006280

Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach

Lategahn J, Hardick J, Grabe T, Niggenaber J, Jeyakumar K, Keul M, Tumbrink H L, Becker C, Hodson L, Kirschner T, Klovekorn P, Ketzer J, Baumann M, Terheyden S, Unger A, Weisner J, Muller M P, van Otterlo W A L, Bauer S, Rauh D. J Med Chem. 2020; 63 (20): 11725-11755. doi: 10.1021/acs.jmedchem.0c00870

Anti-leukemic Effect of CDK9 Inhibition in T-cell Prolymphocytic Leukemia

Johansson P, Dierichs L, Klein-Hitpass L, Bergmann A K, Mollmann M, Menninger S, Habenberger P, Klebl B, Siveke J T, Duhrsen U, Choidas A, Durig J. Ther Adv Hematol. 2020; 11 2040620720933761. doi: 10.1177/2040620720933761

Development of a PDEδ-Targeting PROTACs that Impair Lipid Metabolism

Winzker M, Friese A, Koch U, Janning P, Ziegler S, Waldmann H. Angew Chem Int Ed Engl. 2020; 59 (14): 5595-5601. doi: 10.1002/anie.201913904

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