Publikationen

2025

Highly potent quinoxalinediones inhibit alpha-hemolysin and ameliorate Staphylococcus aureus lung infections

Shekhar A, Di Lucrezia R, Jerye K, Korotkov V S, Harmrolfs K, Rox K, Weich H A, Ghai I, Delhommel F, Becher I, Degenhart C, Fansa E, Unger A, Habenberger P, Klebl B, Lukat P, Schmelz S, Henke S, Borgert S, Lang J C, Sasse F, Diestel R, Richter C, Schneider-Daum N, Hinkelmann B, Niemz J, Lehr C M, Jansch L, Huehn J, Alm R, Savitski M, Welte T, Hesterkamp T, Sattler M, Winterhalter M, Blankenfeldt W, Medina E, Bilitewski U, Dinkel K and Bronstrup M. Cell Host Microbe. 2025; 33 (4): 560-572 e521. doi: 10.1016/j.chom.2025.03.006

The P2X7R-antagonist AFC-5128 ameliorates chronic experimental autoimmune encephalomyelitis in a preventive and therapeutic paradigm

Hoffrogge R, Karachunskaya A, Heitmann N, Pedreiturria X, Kloster K, Bader V, Winklhofer K F, Hamacher M, Klebl B, Gold R, Dinkel K, Kleiter I and Faissner S. Front Immunol. 2025; 16 1554999. doi: 10.3389/fimmu.2025.1554999

Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach

Cherukupalli S, Degenhart C, Habenberger P, Unger A, Eickhoff J, Hoff B H and Sundby E. Pharmaceuticals. 2025; 18 (6): doi: 10.3390/ph18060814

P2X7R antagonism suppresses long-lasting hyperexcitability following traumatic brain injury in mice

Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, Mitra M, Fernandez Martin A, Menendez Mendez A, Wang Y, Ryzwesky Strogulsky N, Sun M, Melia C, Conte G, Plaza-Garcia S, Khalin I, Teng X, Plesnila N, Klebl B, Dinkel K, Hamacher M, Bhattarcharya A, Ceusters M, Palmer J, Loane D, Llop J, Henshall D and Engel T. Theranostics. 2025; 15 (4): 1399-1419. doi: 10.7150/thno.97254

2011

Natural product-inspired cascade synthesis yields modulators of centrosome integrity

Duckert H, Pries V, Khedkar V, Menninger S, Bruss H, Bird A W, Maliga Z, Brockmeyer A, Janning P, Hyman A, Grimme S, Schurmann M, Preut H, Hubel K, Ziegler S, Kumar K, Waldmann H. Nat Chem Biol. 2011; 8 (2): 179-184. doi: 10.1038/nchembio.758

Recruitment of cyclin-dependent kinase 9 to nuclear compartments during cytomegalovirus late replication: importance of an interaction between viral pUL69 and cyclin T1

Feichtinger S, Stamminger T, Muller R, Graf L, Klebl B, Eickhoff J, Marschall M. J Gen Virol. 2011; 92 (Pt 7): 1519-1531. doi: 10.1099/vir.0.030494-0

Structure-guided development of selective RabGGTase inhibitors

Bon R S, Guo Z, Stigter E A, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody R S, Waldmann H. Angew Chem Int Ed Engl. 2011; 50 (21): 4957-4961. doi: 10.1002/anie.201101210

Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile

Radtke L, Willot M, Sun H, Ziegler S, Sauerland S, Strohmann C, Frohlich R, Habenberger P, Waldmann H, Christmann M. Angew Chem Int Ed Engl. 2011; 50 (17): 3998-4002. doi: 10.1002/anie.201007790

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6Hindolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay A C, Conte I, Ercolani C, Zaramella S, Palumbi M C, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M. J Med Chem. 2011; 54 (1): 289-301. doi: 10.1021/jm1013105

Protein Kinases as Drug Targets: 49 (Methods and Principles in Medicinal Chemistry)

Klebl B, Müller G, Hamacher M, Mannhold R, Kubinyi H, Folkers G. 2011. 1 ed. ‎ Wiley-VCH Verlag GmbH & Co. KGaA.

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