Publikationen

2025

Highly potent quinoxalinediones inhibit alpha-hemolysin and ameliorate Staphylococcus aureus lung infections

Shekhar A, Di Lucrezia R, Jerye K, Korotkov V S, Harmrolfs K, Rox K, Weich H A, Ghai I, Delhommel F, Becher I, Degenhart C, Fansa E, Unger A, Habenberger P, Klebl B, Lukat P, Schmelz S, Henke S, Borgert S, Lang J C, Sasse F, Diestel R, Richter C, Schneider-Daum N, Hinkelmann B, Niemz J, Lehr C M, Jansch L, Huehn J, Alm R, Savitski M, Welte T, Hesterkamp T, Sattler M, Winterhalter M, Blankenfeldt W, Medina E, Bilitewski U, Dinkel K and Bronstrup M. Cell Host Microbe. 2025; 33 (4): 560-572 e521. doi: 10.1016/j.chom.2025.03.006

The P2X7R-antagonist AFC-5128 ameliorates chronic experimental autoimmune encephalomyelitis in a preventive and therapeutic paradigm

Hoffrogge R, Karachunskaya A, Heitmann N, Pedreiturria X, Kloster K, Bader V, Winklhofer K F, Hamacher M, Klebl B, Gold R, Dinkel K, Kleiter I and Faissner S. Front Immunol. 2025; 16 1554999. doi: 10.3389/fimmu.2025.1554999

Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach

Cherukupalli S, Degenhart C, Habenberger P, Unger A, Eickhoff J, Hoff B H and Sundby E. Pharmaceuticals. 2025; 18 (6): doi: 10.3390/ph18060814

P2X7R antagonism suppresses long-lasting hyperexcitability following traumatic brain injury in mice

Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, Mitra M, Fernandez Martin A, Menendez Mendez A, Wang Y, Ryzwesky Strogulsky N, Sun M, Melia C, Conte G, Plaza-Garcia S, Khalin I, Teng X, Plesnila N, Klebl B, Dinkel K, Hamacher M, Bhattarcharya A, Ceusters M, Palmer J, Loane D, Llop J, Henshall D and Engel T. Theranostics. 2025; 15 (4): 1399-1419. doi: 10.7150/thno.97254

2014

Cheminformatics at the interface of medicinal chemistry and proteomics

Koch U, Hamacher M, Nussbaumer P. Biochim Biophys Acta. 2014; 1844 (1 Pt A): 156-161. doi: 10.1016/j.bbapap.2013.05.010

Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells

Kelso T W, Baumgart K, Eickhoff J, Albert T, Antrecht C, Lemcke S, Klebl B, Meisterernst M. Mol Cell Biol. 2014; 34 (19): 3675-3688. doi: 10.1128/MCB.00595-14

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site

Zimmermann G, Schultz-Fademrecht C, Kuchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H. J Med Chem. 2014; 57 (12): 5435-5448. doi: 10.1021/jm500632s

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson A M, Langdon W Y, Ikeda F, Fededa J P, Cronin S J, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl B M, Penninger J M. Nature. 2014; 507 (7493): 508-512. doi: 10.1038/nature12998

Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor

Albert T K, Rigault C, Eickhoff J, Baumgart K, Antrecht C, Klebl B, Mittler G, Meisterernst M. Br J Pharmacol. 2014; 171 (1): 55-68. doi: 10.1111/bph.12408

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