Publikationen

2013

Stabilization of physical RAF/14-3-3 interaction by Cotylenin A as treatment strategy for RAS mutant cancers

Molzan M, Kasper S, Roglin L, Skwarczynska M, Sassa T, Inoue T, Breitenbuecher F, Ohkanda J, Kato N, Schuler M, Ottmann C. ACS Chem Biol. 2013; 8 (9): 1869-1875. doi: 10.1021/cb4003464

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker C F, Zerweck J, Schutkowski M, Steegborn C. Nat Commun. 2013; 4 2327. doi: 10.1038/ncomms3327

Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound Design

Richters A, Ketzer J, Getlik M, Grutter C, Schneider R, Heuckmann J M, Heynck S, Sos M L, Gupta A, Unger A, Schultz-Fademrecht C, Thomas R K, Bauer S, Rauh D. J Med Chem. 2013; 56 (14): 5757-5772. doi: 10.1021/jm4004076

Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat

Manley N C, Caso J R, Works M G, Cutler A B, Zemlyak I, Sun G, Munhoz C D, Chang S, Sorrells S F, Ermini F V, Decker J H, Bertrand A A, Dinkel K M, Steinberg G K, Sapolsky R M. PLoS One. 2013; 8 (4): e61789. doi: 10.1371/journal.pone.0061789

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

Reinhardt P, Schmid B, Burbulla L F, Schondorf D C, Wagner L, Glatza M, Hoing S, Hargus G, Heck S A, Dhingra A, Wu G, Muller S, Brockmann K, Kluba T, Maisel M, Kruger R, Berg D, Tsytsyura Y, Thiel C S, Psathaki O E, Klingauf J, Kuhlmann T, Klewin M, Muller H, Gasser T, Scholer H R, Sterneckert J. Cell Stem Cell. 2013; 12 (3): 354-367. doi: 10.1016/j.stem.2013.01.008

Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface

De Vries-van Leeuwen I J, da Costa Pereira D, Flach K D, Piersma S R, Haase C, Bier D, Yalcin Z, Michalides R, Feenstra K A, Jimenez C R, de Greef T F, Brunsveld L, Ottmann C, Zwart W, de Boer A H. Proc Natl Acad Sci U S A. 2013; 110 (22): 8894-8899. doi: 10.1073/pnas.1220809110

Activation of NF-κB signalling by fusicoccin-induced dimerization

Skwarczynska M, Molzan M, Ottmann C. Proc Natl Acad Sci U S A. 2013; 110 (5): E377-386. doi: 10.1073/pnas.1212990110

Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

Wang Y, Kirschner A, Fabian A K, Gopalakrishnan R, Kress C, Hoogeland B, Koch U, Kozany C, Bracher A, Hausch F. J Med Chem. 2013; 56 (10): 3922-3935. doi: 10.1021/jm400087k

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