Publikationen

2024
Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target

Marschall M, Schutz M, Wild M, Socher E, Wangen C, Dhotre K, Rawlinson W D and Sticht H. Cells. 2024; 13 (16): doi: 10.3390/cells13161338

Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity

Jiang S, Yuan T, Rosenberger F A, Mourier A, Dragano N R V, Kremer L S, Rubalcava-Gracia D, Hansen F M, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis M H, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath J R, Krook A, Giavalisco P, Mann M and Larsson N G. Nat Metab. 2024; 6 (6): 1024-1035. doi: 10.1038/s42255-024-01038-3

Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction

Andlovic B, Valenti D, Centorrino F, Picarazzi F, Hristeva S, Hiltmann M, Wolf A, Cantrelle F X, Mori M, Landrieu I, Levy L M, Klebl B, Tzalis D, Genski T, Eickhoff J and Ottmann C. Biochemistry. 2024; 63 (17): 2196-2206. doi: 10.1021/acs.biochem.4c00248

An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity

Yu D, Wagner S, Schutz M, Jeon Y, Seo M, Kim J, Bruckner N, Kicuntod J, Tillmanns J, Wangen C, Hahn F, Kaufer B B, Neipel F, Eickhoff J, Klebl B, Nam K and Marschall M. Pharmaceutics. 2024; 16 (2): doi: 10.3390/pharmaceutics16020158

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

Popović L, Wintgens J P, Wu Y, Brankatschk B, Menninger S, Degenhart C, Jensen N, Wichert S P, Klebl B, Rossner M J and Wehr M C. iScience. 2024; doi: 10.1016/j.isci.2024.108839

Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland

Bjornstad F, Havik S, Aarhus T I, Mahdi I, Unger A, Habenberger P, Degenhart C, Eickhoff J, Klebl B M, Sundby E and Hoff B H. Eur J Med Chem. 2024; 265 116053. doi: 10.1016/j.ejmech.2023.116053

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

Teuber A, Schulz T, Fletcher B S, Gontla R, Muhlenberg T, Zischinsky M L, Niggenaber J, Weisner J, Kleinbolting S B, Lategahn J, Sievers S, Muller M P, Bauer S and Rauh D. Nat Commun. 2024; 15 (1): 63. doi: 10.1038/s41467-023-44376-8

2013
Stabilization of physical RAF/14-3-3 interaction by Cotylenin A as treatment strategy for RAS mutant cancers

Molzan M, Kasper S, Roglin L, Skwarczynska M, Sassa T, Inoue T, Breitenbuecher F, Ohkanda J, Kato N, Schuler M, Ottmann C. ACS Chem Biol. 2013; 8 (9): 1869-1875. doi: 10.1021/cb4003464

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker C F, Zerweck J, Schutkowski M, Steegborn C. Nat Commun. 2013; 4 2327. doi: 10.1038/ncomms3327

Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound Design

Richters A, Ketzer J, Getlik M, Grutter C, Schneider R, Heuckmann J M, Heynck S, Sos M L, Gupta A, Unger A, Schultz-Fademrecht C, Thomas R K, Bauer S, Rauh D. J Med Chem. 2013; 56 (14): 5757-5772. doi: 10.1021/jm4004076

Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat

Manley N C, Caso J R, Works M G, Cutler A B, Zemlyak I, Sun G, Munhoz C D, Chang S, Sorrells S F, Ermini F V, Decker J H, Bertrand A A, Dinkel K M, Steinberg G K, Sapolsky R M. PLoS One. 2013; 8 (4): e61789. doi: 10.1371/journal.pone.0061789

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

Reinhardt P, Schmid B, Burbulla L F, Schondorf D C, Wagner L, Glatza M, Hoing S, Hargus G, Heck S A, Dhingra A, Wu G, Muller S, Brockmann K, Kluba T, Maisel M, Kruger R, Berg D, Tsytsyura Y, Thiel C S, Psathaki O E, Klingauf J, Kuhlmann T, Klewin M, Muller H, Gasser T, Scholer H R, Sterneckert J. Cell Stem Cell. 2013; 12 (3): 354-367. doi: 10.1016/j.stem.2013.01.008

Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface

De Vries-van Leeuwen I J, da Costa Pereira D, Flach K D, Piersma S R, Haase C, Bier D, Yalcin Z, Michalides R, Feenstra K A, Jimenez C R, de Greef T F, Brunsveld L, Ottmann C, Zwart W, de Boer A H. Proc Natl Acad Sci U S A. 2013; 110 (22): 8894-8899. doi: 10.1073/pnas.1220809110

Activation of NF-κB signalling by fusicoccin-induced dimerization

Skwarczynska M, Molzan M, Ottmann C. Proc Natl Acad Sci U S A. 2013; 110 (5): E377-386. doi: 10.1073/pnas.1212990110

Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

Wang Y, Kirschner A, Fabian A K, Gopalakrishnan R, Kress C, Hoogeland B, Koch U, Kozany C, Bracher A, Hausch F. J Med Chem. 2013; 56 (10): 3922-3935. doi: 10.1021/jm400087k