2013
Stabilization of physical RAF/14-3-3 interaction by Cotylenin A as treatment strategy for RAS mutant cancersMolzan M, Kasper S, Roglin L, Skwarczynska M, Sassa T, Inoue T, Breitenbuecher F, Ohkanda J, Kato N, Schuler M, Ottmann C. ACS Chem Biol. 2013; 8 (9): 1869-1875. doi: 10.1021/cb4003464
An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoformsRauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker C F, Zerweck J, Schutkowski M, Steegborn C. Nat Commun. 2013; 4 2327. doi: 10.1038/ncomms3327
Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound DesignRichters A, Ketzer J, Getlik M, Grutter C, Schneider R, Heuckmann J M, Heynck S, Sos M L, Gupta A, Unger A, Schultz-Fademrecht C, Thomas R K, Bauer S, Rauh D. J Med Chem. 2013; 56 (14): 5757-5772. doi: 10.1021/jm4004076
Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured ratManley N C, Caso J R, Works M G, Cutler A B, Zemlyak I, Sun G, Munhoz C D, Chang S, Sorrells S F, Ermini F V, Decker J H, Bertrand A A, Dinkel K M, Steinberg G K, Sapolsky R M. PLoS One. 2013; 8 (4): e61789. doi: 10.1371/journal.pone.0061789
Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene ExpressionReinhardt P, Schmid B, Burbulla L F, Schondorf D C, Wagner L, Glatza M, Hoing S, Hargus G, Heck S A, Dhingra A, Wu G, Muller S, Brockmann K, Kluba T, Maisel M, Kruger R, Berg D, Tsytsyura Y, Thiel C S, Psathaki O E, Klingauf J, Kuhlmann T, Klewin M, Muller H, Gasser T, Scholer H R, Sterneckert J. Cell Stem Cell. 2013; 12 (3): 354-367. doi: 10.1016/j.stem.2013.01.008
Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interfaceDe Vries-van Leeuwen I J, da Costa Pereira D, Flach K D, Piersma S R, Haase C, Bier D, Yalcin Z, Michalides R, Feenstra K A, Jimenez C R, de Greef T F, Brunsveld L, Ottmann C, Zwart W, de Boer A H. Proc Natl Acad Sci U S A. 2013; 110 (22): 8894-8899. doi: 10.1073/pnas.1220809110
Activation of NF-κB signalling by fusicoccin-induced dimerizationSkwarczynska M, Molzan M, Ottmann C. Proc Natl Acad Sci U S A. 2013; 110 (5): E377-386. doi: 10.1073/pnas.1212990110
Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational ControlWang Y, Kirschner A, Fabian A K, Gopalakrishnan R, Kress C, Hoogeland B, Koch U, Kozany C, Bracher A, Hausch F. J Med Chem. 2013; 56 (10): 3922-3935. doi: 10.1021/jm400087k