Publikationen

2026

Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1

Krings K S, Hatzfeld J, Weller S, Borkowski N, Llewellyn T R, Schmitt L, Scherer B, Itkonen H M, Peter C, Stork B, Geyh S, Eickhoff J, Klebl B, Qin N, Essmann F and Wesselborg S. Cell Death Dis. 2026; 17 (1): doi: 10.1038/s41419-026-08889-6

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor alpha-Hemolysin by Blocking the Pullout of Its Stem Domain

Korotkov V S, Lukat P, Di Lucrezia R, Shekhar A, Degenhart C, Diestel R, Bilitewski U, Dinkel K, Blankenfeldt W and Bronstrup M. ChemMedChem. 2026; 21 (4): e202501098. doi: 10.1002/cmdc.202501098

Reducing PI4KIIIalpha Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical Neurons

Clemente E, Sivasubramanian R, Kordes S, Bhatia P, Hans R, Vogel S, Baumann M, Klebl B and Sterneckert J. Cells. 2026; 15 (13): doi: 10.3390/cells15131228

Towards selective peptide deformylase inhibitors: A mass spectrometry-based evaluation of in cellulo activity of actinonin and bromoindole derivatives

Bachmann N, Schultz A, Zouatom M, Zhou T, Degenhart C, Koch U, Schakermann S, Huning J, Heinrich S, Dal Molin M, Zischinsky M L, Tourel S, Klebl A K, Rybniker J, Klebl B M, Scherkenbeck J and Bandow J E. Eur J Med Chem. 2026; 308 118678. doi: 10.1016/j.ejmech.2026.118678

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics

Al Kabbani M A, Jatoo P, Klebl A K, Klebl B and Zempel H. PLoS One. 2026; 21 (3): e0339922. doi: 10.1371/journal.pone.0339922

2012

Development of Selective, Potent RabGGTase Inhibitors

Stigter E A, Guo Z, Bon R S, Wu Y W, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody R S. J Med Chem. 2012; 55 (19): 8330-8340. doi: 10.1021/jm300624s

Amorfrutins are potent antidiabetic dietary natural products

Weidner C, de Groot J C, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han C T, Giegold S, Baumann M, Klebl B, Siems K, Muller-Kuhrt L, Schurmann A, Schuler R, Pfeiffer A F, Schroeder F C, Bussow K, Sauer S. Proc Natl Acad Sci U S A. 2012; 109 (19): 7257-7262. doi: 10.1073/pnas.1116971109

Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase

Deraeve C, Guo Z, Bon R S, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter E A, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody R S, Wu Y W. J Am Chem Soc. 2012; 134 (17): 7384-7391. doi: 10.1021/ja211305j

Ja wir nutzen Cookies,

Publikationen

Archiv