Publikationen

2024
Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

Popović L, Wintgens J P, Wu Y, Brankatschk B, Menninger S, Degenhart C, Jensen N, Wichert S P, Klebl B, Rossner M J and Wehr M C. iScience. 2024; doi: 10.1016/j.isci.2024.108839

Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland

Bjornstad F, Havik S, Aarhus T I, Mahdi I, Unger A, Habenberger P, Degenhart C, Eickhoff J, Klebl B M, Sundby E and Hoff B H. Eur J Med Chem. 2024; 265 116053. doi: 10.1016/j.ejmech.2023.116053

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

Teuber A, Schulz T, Fletcher B S, Gontla R, Muhlenberg T, Zischinsky M L, Niggenaber J, Weisner J, Kleinbolting S B, Lategahn J, Sievers S, Muller M P, Bauer S and Rauh D. Nat Commun. 2024; 15 (1): 63. doi: 10.1038/s41467-023-44376-8

2012
Development of Selective, Potent RabGGTase Inhibitors

Stigter E A, Guo Z, Bon R S, Wu Y W, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody R S. J Med Chem. 2012; 55 (19): 8330-8340. doi: 10.1021/jm300624s

Amorfrutins are potent antidiabetic dietary natural products

Weidner C, de Groot J C, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han C T, Giegold S, Baumann M, Klebl B, Siems K, Muller-Kuhrt L, Schurmann A, Schuler R, Pfeiffer A F, Schroeder F C, Bussow K, Sauer S. Proc Natl Acad Sci U S A. 2012; 109 (19): 7257-7262. doi: 10.1073/pnas.1116971109

Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase

Deraeve C, Guo Z, Bon R S, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter E A, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody R S, Wu Y W. J Am Chem Soc. 2012; 134 (17): 7384-7391. doi: 10.1021/ja211305j