Publikationen

2026

Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1

Krings K S, Hatzfeld J, Weller S, Borkowski N, Llewellyn T R, Schmitt L, Scherer B, Itkonen H M, Peter C, Stork B, Geyh S, Eickhoff J, Klebl B, Qin N, Essmann F and Wesselborg S. Cell Death Dis. 2026; 17 (1): doi: 10.1038/s41419-026-08889-6

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor alpha-Hemolysin by Blocking the Pullout of Its Stem Domain

Korotkov V S, Lukat P, Di Lucrezia R, Shekhar A, Degenhart C, Diestel R, Bilitewski U, Dinkel K, Blankenfeldt W and Bronstrup M. ChemMedChem. 2026; 21 (4): e202501098. doi: 10.1002/cmdc.202501098

Reducing PI4KIIIalpha Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical Neurons

Clemente E, Sivasubramanian R, Kordes S, Bhatia P, Hans R, Vogel S, Baumann M, Klebl B and Sterneckert J. Cells. 2026; 15 (13): doi: 10.3390/cells15131228

Towards selective peptide deformylase inhibitors: A mass spectrometry-based evaluation of in cellulo activity of actinonin and bromoindole derivatives

Bachmann N, Schultz A, Zouatom M, Zhou T, Degenhart C, Koch U, Schakermann S, Huning J, Heinrich S, Dal Molin M, Zischinsky M L, Tourel S, Klebl A K, Rybniker J, Klebl B M, Scherkenbeck J and Bandow J E. Eur J Med Chem. 2026; 308 118678. doi: 10.1016/j.ejmech.2026.118678

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics

Al Kabbani M A, Jatoo P, Klebl A K, Klebl B and Zempel H. PLoS One. 2026; 21 (3): e0339922. doi: 10.1371/journal.pone.0339922

2018

Wege zu neuen Medikamenten

Nussbaumer P, Klebl B. Nachrichten aus der Chemie. 2018; 66 (10): 976-978. doi: 10.1002/nadc.20184074752

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps

Sollberger G, Choidas A, Burn G L, Habenberger P, Di Lucrezia R, Kordes S, Menninger S, Eickhoff J, Nussbaumer P, Klebl B, Kruger R, Herzig A, Zychlinsky A. Sci Immunol. 2018; 3 (26): doi: 10.1126/sciimmunol.aar6689

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A

Cheung S Y, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy H N, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote S J, Christmann M, Waldmann H, Abbas S K, Beech D J, Vasudev N S. Oncotarget. 2018; 9 (51): 29634-29643. doi: 10.18632/oncotarget.25659

Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as novel AXL kinase inhibitors

Szabadkai I, Torka R, Garamvolgyi R, Baska F, Gyulavari P, Boros S, Illyes E, Choidas A, Ullrich A, Orfi L. J Med Chem. 2018; 61 (14): 6277-6292. doi: 10.1021/acs.jmedchem.8b00672

Challenging Medicinal Chemistry: Ups and Downs in a Drug Discovery Project

Nussbaumer P. Chemical Monthly. 2018; 149 1191-1197

Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia

Gothert J R, Imsak R, Mollmann M, Kesper S, Gobel M, Duhrsen U, Scholz A, Lucking U, Baumann M, Unger A, Schultz-Fademrecht C, Klebl B, Eickhoff J, Choidas A, Durig J. Oncotarget. 2018; 9 (41): 26353-26369. doi: 10.18632/oncotarget.25293

Modulators of 14-3-3 protein-protein interactions

Stevers L M, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson A J, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston R G, Brunsveld L, Ottmann C. J Med Chem. 2018; 61 (9): 3755-3778. doi: 10.1021/acs.jmedchem.7b00574

Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against chlamydia infection

Rother M, Gonzalez E, Teixeira da Costa A R, Wask L, Gravenstein I, Pardo M, Pietzke M, Gurumurthy R K, Angermann J, Laudeley R, Glage S, Meyer M, Chumduri C, Kempa S, Dinkel K, Unger A, Klebl B, Klos A, Meyer T F. Cell Host Microbe. 2018; 23 (5): 661-671 e668. doi: 10.1016/j.chom.2018.04.002

Identification of non-catalytic lysine residues from allosteric circuits via covalent probes

Bongard J, Lorenz M, Vetter I R, Stege P, Porfetye A T, Schmitz A L, Kaschani F, Wolf A, Koch U, Nussbaumer P, Klebl B, Kaiser M, Ehrmann M. ACS Chem Biol. 2018; 13 (5): 1307-1312. doi: 10.1021/acschembio.8b00101

Interaction of KRas4B protein with C6-ceramide containing lipid model membranes

Li L, Dwivedi M, Erwin N, Mobitz S, Nussbaumer P, Winter R. Biochim Biophys Acta Biomembr. 2018; 1860 (5): 1008-1014. doi: 10.1016/j.bbamem.2018.01.016

Identification of an (-)-Englerin A analogue which antagonizes (-)-Englerin A at TRPC1/4/5 channels

Rubaiy H N, Seitz T, Hahn S, Choidas A, Habenberger P, Klebl B, Dinkel K, Nussbaumer P, Waldmann H, Christmann M, Beech D J. Br J Pharmacol. 2018; 175 (5): 830-839. doi: 10.1111/bph.14128

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein

Hoing S, Yeh T Y, Baumann M, Martinez N E, Habenberger P, Kremer L, Drexler H C A, Kuchler P, Reinhardt P, Choidas A, Zischinsky M L, Zischinsky G, Nandini S, Ledray A P, Ketcham S A, Reinhardt L, Abo-Rady M, Glatza M, King S J, Nussbaumer P, Ziegler S, Klebl B, Schroer T A, Scholer H R, Waldmann H, Sterneckert J. Cell Chem Biol. 2018; 25 (4): 357-369 e356. doi: 10.1016/j.chembiol.2017.12.014

SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia

Johansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, Duhrsen U, Kuppers R, Durig J. Blood Cancer J. 2018; 8 (1): 11. doi: 10.1038/s41408-017-0036-5

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