Scientific Journals and Books

2026

Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1

Krings K S, Hatzfeld J, Weller S, Borkowski N, Llewellyn T R, Schmitt L, Scherer B, Itkonen H M, Peter C, Stork B, Geyh S, Eickhoff J, Klebl B, Qin N, Essmann F and Wesselborg S. Cell Death Dis. 2026; 17 (1): doi: 10.1038/s41419-026-08889-6

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor alpha-Hemolysin by Blocking the Pullout of Its Stem Domain

Korotkov V S, Lukat P, Di Lucrezia R, Shekhar A, Degenhart C, Diestel R, Bilitewski U, Dinkel K, Blankenfeldt W and Bronstrup M. ChemMedChem. 2026; 21 (4): e202501098. doi: 10.1002/cmdc.202501098

Reducing PI4KIIIalpha Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical Neurons

Clemente E, Sivasubramanian R, Kordes S, Bhatia P, Hans R, Vogel S, Baumann M, Klebl B and Sterneckert J. Cells. 2026; 15 (13): doi: 10.3390/cells15131228

Towards selective peptide deformylase inhibitors: A mass spectrometry-based evaluation of in cellulo activity of actinonin and bromoindole derivatives

Bachmann N, Schultz A, Zouatom M, Zhou T, Degenhart C, Koch U, Schakermann S, Huning J, Heinrich S, Dal Molin M, Zischinsky M L, Tourel S, Klebl A K, Rybniker J, Klebl B M, Scherkenbeck J and Bandow J E. Eur J Med Chem. 2026; 308 118678. doi: 10.1016/j.ejmech.2026.118678

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics

Al Kabbani M A, Jatoo P, Klebl A K, Klebl B and Zempel H. PLoS One. 2026; 21 (3): e0339922. doi: 10.1371/journal.pone.0339922

2025

Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors

Cherukupalli S, Eickhoff J, Degenhart C, Habenberger P, Unger A, Hoff B H and Sundby E. Molecules. 2025; 30 (12): doi: 10.3390/molecules30122641

P2X7 receptor antagonism suppresses epileptiform-like activity in an inflammation-primed human iPSC-derived neuron model of drug-resistant epilepsy

Kesavan J, Wang Y, Dinkel K, Hamacher M, Prehn J H M, Henshall D C and Engel T. Br J Pharmacol. 2025; doi: 10.1111/bph.70167

Highly potent quinoxalinediones inhibit alpha-hemolysin and ameliorate Staphylococcus aureus lung infections

Shekhar A, Di Lucrezia R, Jerye K, Korotkov V S, Harmrolfs K, Rox K, Weich H A, Ghai I, Delhommel F, Becher I, Degenhart C, Fansa E, Unger A, Habenberger P, Klebl B, Lukat P, Schmelz S, Henke S, Borgert S, Lang J C, Sasse F, Diestel R, Richter C, Schneider-Daum N, Hinkelmann B, Niemz J, Lehr C M, Jansch L, Huehn J, Alm R, Savitski M, Welte T, Hesterkamp T, Sattler M, Winterhalter M, Blankenfeldt W, Medina E, Bilitewski U, Dinkel K and Bronstrup M. Cell Host Microbe. 2025; 33 (4): 560-572 e521. doi: 10.1016/j.chom.2025.03.006

The P2X7R-antagonist AFC-5128 ameliorates chronic experimental autoimmune encephalomyelitis in a preventive and therapeutic paradigm

Hoffrogge R, Karachunskaya A, Heitmann N, Pedreiturria X, Kloster K, Bader V, Winklhofer K F, Hamacher M, Klebl B, Gold R, Dinkel K, Kleiter I and Faissner S. Front Immunol. 2025; 16 1554999. doi: 10.3389/fimmu.2025.1554999

Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach

Cherukupalli S, Degenhart C, Habenberger P, Unger A, Eickhoff J, Hoff B H and Sundby E. Pharmaceuticals. 2025; 18 (6): doi: 10.3390/ph18060814

RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma

Egea-Rodriguez S, Varaljai R, Nordmann T M, Lubis R, Philip M, Rambow F, Roesch A, Flaig M, Horn S, Stoll R, Zhao F, Paschen A, Klebl B, Hickson I D, Schadendorf D, Mann M and Helfrich I. Clin Transl Med. 2025; 15 (1): e70094. doi: 10.1002/ctm2.70094

P2X7R antagonism suppresses long-lasting hyperexcitability following traumatic brain injury in mice

Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, Mitra M, Fernandez Martin A, Menendez Mendez A, Wang Y, Ryzwesky Strogulsky N, Sun M, Melia C, Conte G, Plaza-Garcia S, Khalin I, Teng X, Plesnila N, Klebl B, Dinkel K, Hamacher M, Bhattarcharya A, Ceusters M, Palmer J, Loane D, Llop J, Henshall D and Engel T. Theranostics. 2025; 15 (4): 1399-1419. doi: 10.7150/thno.97254

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