2014
Cheminformatics at the interface of medicinal chemistry and proteomicsKoch U, Hamacher M, Nussbaumer P. Biochim Biophys Acta. 2014; 1844 (1 Pt A): 156-161. doi: 10.1016/j.bbapap.2013.05.010
Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cellsKelso T W, Baumgart K, Eickhoff J, Albert T, Antrecht C, Lemcke S, Klebl B, Meisterernst M. Mol Cell Biol. 2014; 34 (19): 3675-3688. doi: 10.1128/MCB.00595-14
Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding siteZimmermann G, Schultz-Fademrecht C, Kuchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H. J Med Chem. 2014; 57 (12): 5435-5448. doi: 10.1021/jm500632s
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cellsPaolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson A M, Langdon W Y, Ikeda F, Fededa J P, Cronin S J, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl B M, Penninger J M. Nature. 2014; 507 (7493): 508-512. doi: 10.1038/nature12998
Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitorAlbert T K, Rigault C, Eickhoff J, Baumgart K, Antrecht C, Klebl B, Mittler G, Meisterernst M. Br J Pharmacol. 2014; 171 (1): 55-68. doi: 10.1111/bph.12408