2018
Wege zu neuen MedikamentenNussbaumer P, Klebl B. Nachrichten aus der Chemie. 2018; 66 (10): 976-978. doi: 10.1002/nadc.20184074752
Gasdermin D plays a vital role in the generation of neutrophil extracellular trapsSollberger G, Choidas A, Burn G L, Habenberger P, Di Lucrezia R, Kordes S, Menninger S, Eickhoff J, Nussbaumer P, Klebl B, Kruger R, Herzig A, Zychlinsky A. Sci Immunol. 2018; 3 (26): doi: 10.1126/sciimmunol.aar6689
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin ACheung S Y, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy H N, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote S J, Christmann M, Waldmann H, Abbas S K, Beech D J, Vasudev N S. Oncotarget. 2018; 9 (51): 29634-29643. doi: 10.18632/oncotarget.25659
Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as novel AXL kinase inhibitorsSzabadkai I, Torka R, Garamvolgyi R, Baska F, Gyulavari P, Boros S, Illyes E, Choidas A, Ullrich A, Orfi L. J Med Chem. 2018; 61 (14): 6277-6292. doi: 10.1021/acs.jmedchem.8b00672
Challenging Medicinal Chemistry: Ups and Downs in a Drug Discovery ProjectNussbaumer P. Chemical Monthly. 2018; 149 1191-1197
Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemiaGothert J R, Imsak R, Mollmann M, Kesper S, Gobel M, Duhrsen U, Scholz A, Lucking U, Baumann M, Unger A, Schultz-Fademrecht C, Klebl B, Eickhoff J, Choidas A, Durig J. Oncotarget. 2018; 9 (41): 26353-26369. doi: 10.18632/oncotarget.25293
Modulators of 14-3-3 protein-protein interactionsStevers L M, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson A J, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston R G, Brunsveld L, Ottmann C. J Med Chem. 2018; 61 (9): 3755-3778. doi: 10.1021/acs.jmedchem.7b00574
Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against chlamydia infectionRother M, Gonzalez E, Teixeira da Costa A R, Wask L, Gravenstein I, Pardo M, Pietzke M, Gurumurthy R K, Angermann J, Laudeley R, Glage S, Meyer M, Chumduri C, Kempa S, Dinkel K, Unger A, Klebl B, Klos A, Meyer T F. Cell Host Microbe. 2018; 23 (5): 661-671 e668. doi: 10.1016/j.chom.2018.04.002
Identification of non-catalytic lysine residues from allosteric circuits via covalent probesBongard J, Lorenz M, Vetter I R, Stege P, Porfetye A T, Schmitz A L, Kaschani F, Wolf A, Koch U, Nussbaumer P, Klebl B, Kaiser M, Ehrmann M. ACS Chem Biol. 2018; 13 (5): 1307-1312. doi: 10.1021/acschembio.8b00101
Interaction of KRas4B protein with C6-ceramide containing lipid model membranesLi L, Dwivedi M, Erwin N, Mobitz S, Nussbaumer P, Winter R. Biochim Biophys Acta Biomembr. 2018; 1860 (5): 1008-1014. doi: 10.1016/j.bbamem.2018.01.016
Identification of an (-)-Englerin A analogue which antagonizes (-)-Englerin A at TRPC1/4/5 channelsRubaiy H N, Seitz T, Hahn S, Choidas A, Habenberger P, Klebl B, Dinkel K, Nussbaumer P, Waldmann H, Christmann M, Beech D J. Br J Pharmacol. 2018; 175 (5): 830-839. doi: 10.1111/bph.14128
Dynarrestin, a Novel Inhibitor of Cytoplasmic DyneinHoing S, Yeh T Y, Baumann M, Martinez N E, Habenberger P, Kremer L, Drexler H C A, Kuchler P, Reinhardt P, Choidas A, Zischinsky M L, Zischinsky G, Nandini S, Ledray A P, Ketcham S A, Reinhardt L, Abo-Rady M, Glatza M, King S J, Nussbaumer P, Ziegler S, Klebl B, Schroer T A, Scholer H R, Waldmann H, Sterneckert J. Cell Chem Biol. 2018; 25 (4): 357-369 e356. doi: 10.1016/j.chembiol.2017.12.014
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemiaJohansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, Duhrsen U, Kuppers R, Durig J. Blood Cancer J. 2018; 8 (1): 11. doi: 10.1038/s41408-017-0036-5
