Scientific Journals and Books

2026

Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1

Krings K S, Hatzfeld J, Weller S, Borkowski N, Llewellyn T R, Schmitt L, Scherer B, Itkonen H M, Peter C, Stork B, Geyh S, Eickhoff J, Klebl B, Qin N, Essmann F and Wesselborg S. Cell Death Dis. 2026; 17 (1): doi: 10.1038/s41419-026-08889-6

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor alpha-Hemolysin by Blocking the Pullout of Its Stem Domain

Korotkov V S, Lukat P, Di Lucrezia R, Shekhar A, Degenhart C, Diestel R, Bilitewski U, Dinkel K, Blankenfeldt W and Bronstrup M. ChemMedChem. 2026; 21 (4): e202501098. doi: 10.1002/cmdc.202501098

Reducing PI4KIIIalpha Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical Neurons

Clemente E, Sivasubramanian R, Kordes S, Bhatia P, Hans R, Vogel S, Baumann M, Klebl B and Sterneckert J. Cells. 2026; 15 (13): doi: 10.3390/cells15131228

Towards selective peptide deformylase inhibitors: A mass spectrometry-based evaluation of in cellulo activity of actinonin and bromoindole derivatives

Bachmann N, Schultz A, Zouatom M, Zhou T, Degenhart C, Koch U, Schakermann S, Huning J, Heinrich S, Dal Molin M, Zischinsky M L, Tourel S, Klebl A K, Rybniker J, Klebl B M, Scherkenbeck J and Bandow J E. Eur J Med Chem. 2026; 308 118678. doi: 10.1016/j.ejmech.2026.118678

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics

Al Kabbani M A, Jatoo P, Klebl A K, Klebl B and Zempel H. PLoS One. 2026; 21 (3): e0339922. doi: 10.1371/journal.pone.0339922

2019

Kinase Chemodiversity from the Arctic: The Breitfussins

Hansen K O, Andersen J H, Bayer A, Pandey S K, Lorentzen M, Jorgensen K B, Sydnes M O, Guttormsen Y, Baumann M, Koch U, Klebl B, Eickhoff J, Haug B E, Isaksson J, Hansen E H. J Med Chem. 2019; 62 (22): 10167-10181. doi: 10.1021/acs.jmedchem.9b01006

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi H T, Nihongaki Y, Flegel J, Mejdrova I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Scholer H R, Sterneckert J, Inoue T, Ziegler S, Waldmann H. Angew Chem Int Ed Engl. 2019; 58 (46): 16617-16628. doi: 10.1002/anie.201907632

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

Lategahn J, Keul M, Klovekorn P, Tumbrink H L, Niggenaber J, Muller M P, Hodson L, Flasshoff M, Hardick J, Grabe T, Engel J, Schultz-Fademrecht C, Baumann M, Ketzer J, Muhlenberg T, Hiller W, Gunther G, Unger A, Muller H, Heimsoeth A, Golz C, Blank-Landeshammer B, Kollipara L, Zahedi R P, Strohmann C, Hengstler J G, van Otterlo W A L, Bauer S, Rauh D. Chem Sci. 2019; 10 (46): 10789-10801. doi: 10.1039/c9sc03445e

Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells

Garivet G, Hofer W, Konitsiotis A, Klein C, Kaiser N, Mejuch T, Fansa E, Alsaabi R, Wittinghofer A, Bastiaens P I H, Waldmann H. Cell Chem Biol. 2019; 26 (6): 842-851 e847. doi: 10.1016/j.chembiol.2019.02.019

Analysis and Modelling of False Positives in GPCR Assays

Ghosh D, Tetko I, Klebl B, Nussbaumer P, Koch U. ICANN 2019. 2019; 11731 767-770

Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action

Bongard J, Schmitz A L, Wolf A, Zischinsky G, Pieren M, Schellhorn B, Bravo-Rodriguez K, Schillinger J, Koch U, Nussbaumer P, Klebl B, Steinmann J, Buer J, Sanchez-Garcia E, Ehrmann M, Kaiser M. ChemMedChem. 2019; 14 (11): 1074-1078. doi: 10.1002/cmdc.201900193

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer

Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, Hardick J, Ladigan S, Lindemann M, Smith S, Quambusch L, Scheinpflug R, Depta L, Gontla R, Unger A, Muller H, Baumann M, Schultz-Fademrecht C, Gunther G, Maghnouj A, Muller M P, Pohl M, Teschendorf C, Wolters H, Viebahn R, Tannapfel A, Uhl W, Hengstler J G, Hahn S A, Siveke J T, Rauh D. Cancer Res. 2019; 79 (9): 2367-2378. doi: 10.1158/0008-5472.CAN-18-2861

Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors

Wolle P, Hardick J, Cronin S J F, Engel J, Baumann M, Lategahn J, Penninger J M, Rauh D. J Med Chem. 2019; 62 (5): 2843-2848. doi: 10.1021/acs.jmedchem.9b00102

Dual inhibition of GSK3β and CDK5 protects the cytoskeleton of neurons from neuroinflammatory-mediated degeneration in vitro and in vivo

Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler H C A, Menninger S, Zischinsky G, Eickhoff J, Frob C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson E N, Abo-Rady M, Bickle M, Pandey U B, Reimer M M, Kizil C, Scholer H R, Nussbaumer P, Klebl B, Sterneckert J L. Stem Cell Reports. 2019; 12 (3): 502-517. doi: 10.1016/j.stemcr.2019.01.015

Chronic high dose P2X7 receptor inhibition exacerbates cancer-induced bone pain

Falk S, Appel C K, Bennedbaek H B, Al-Dihaissy T, Unger A, Dinkel K, Heegaard A M. Eur J Pharmacol. 2019; 845 48-55. doi: 10.1016/j.ejphar.2018.12.032

In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model

Sonntag E, Hahn F, Bertzbach L D, Seyler L, Wangen C, Muller R, Tannig P, Grau B, Baumann M, Zent E, Zischinsky G, Eickhoff J, Kaufer B B, Bauerle T, Tsogoeva S B, Marschall M. Antiviral Res. 2019; 161 63-69. doi: 10.1016/j.antiviral.2018.11.008

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