Scientific Journals and Books

2026

Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1

Krings K S, Hatzfeld J, Weller S, Borkowski N, Llewellyn T R, Schmitt L, Scherer B, Itkonen H M, Peter C, Stork B, Geyh S, Eickhoff J, Klebl B, Qin N, Essmann F and Wesselborg S. Cell Death Dis. 2026; 17 (1): doi: 10.1038/s41419-026-08889-6

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor alpha-Hemolysin by Blocking the Pullout of Its Stem Domain

Korotkov V S, Lukat P, Di Lucrezia R, Shekhar A, Degenhart C, Diestel R, Bilitewski U, Dinkel K, Blankenfeldt W and Bronstrup M. ChemMedChem. 2026; 21 (4): e202501098. doi: 10.1002/cmdc.202501098

Reducing PI4KIIIalpha Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical Neurons

Clemente E, Sivasubramanian R, Kordes S, Bhatia P, Hans R, Vogel S, Baumann M, Klebl B and Sterneckert J. Cells. 2026; 15 (13): doi: 10.3390/cells15131228

Towards selective peptide deformylase inhibitors: A mass spectrometry-based evaluation of in cellulo activity of actinonin and bromoindole derivatives

Bachmann N, Schultz A, Zouatom M, Zhou T, Degenhart C, Koch U, Schakermann S, Huning J, Heinrich S, Dal Molin M, Zischinsky M L, Tourel S, Klebl A K, Rybniker J, Klebl B M, Scherkenbeck J and Bandow J E. Eur J Med Chem. 2026; 308 118678. doi: 10.1016/j.ejmech.2026.118678

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics

Al Kabbani M A, Jatoo P, Klebl A K, Klebl B and Zempel H. PLoS One. 2026; 21 (3): e0339922. doi: 10.1371/journal.pone.0339922

2020

Small-molecule Inhibitors of Human Mitochondrial DNA Transcription

Bonekamp N A, Peter B, Hillen H S, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel M S, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson C M, Larsson N G. Nature. 2020; 588 (7839): 712-716. doi: 10.1038/s41586-020-03048-z

TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics

Kunig V B K, Potowski M, Akbarzadeh M, Klika Skopic M, Dos Santos Smith D, Arendt L, Dormuth I, Adihou H, Andlovic B, Karatas H, Shaabani S, Zarganes-Tzitzikas T, Neochoritis C G, Zhang R, Groves M, Gueret S M, Ottmann C, Rahnenfuhrer J, Fried R, Domling A, Brunschweiger A. Angew Chem Int Ed Engl. 2020; 59 (46): 20338-20342. doi: 10.1002/anie.202006280

Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach

Lategahn J, Hardick J, Grabe T, Niggenaber J, Jeyakumar K, Keul M, Tumbrink H L, Becker C, Hodson L, Kirschner T, Klovekorn P, Ketzer J, Baumann M, Terheyden S, Unger A, Weisner J, Muller M P, van Otterlo W A L, Bauer S, Rauh D. J Med Chem. 2020; 63 (20): 11725-11755. doi: 10.1021/acs.jmedchem.0c00870

Anti-leukemic Effect of CDK9 Inhibition in T-cell Prolymphocytic Leukemia

Johansson P, Dierichs L, Klein-Hitpass L, Bergmann A K, Mollmann M, Menninger S, Habenberger P, Klebl B, Siveke J T, Duhrsen U, Choidas A, Durig J. Ther Adv Hematol. 2020; 11 2040620720933761. doi: 10.1177/2040620720933761

Development of a PDEδ-Targeting PROTACs that Impair Lipid Metabolism

Winzker M, Friese A, Koch U, Janning P, Ziegler S, Waldmann H. Angew Chem Int Ed Engl. 2020; 59 (14): 5595-5601. doi: 10.1002/anie.201913904

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