Scientific Journals and Books

2025

Highly potent quinoxalinediones inhibit alpha-hemolysin and ameliorate Staphylococcus aureus lung infections

Shekhar A, Di Lucrezia R, Jerye K, Korotkov V S, Harmrolfs K, Rox K, Weich H A, Ghai I, Delhommel F, Becher I, Degenhart C, Fansa E, Unger A, Habenberger P, Klebl B, Lukat P, Schmelz S, Henke S, Borgert S, Lang J C, Sasse F, Diestel R, Richter C, Schneider-Daum N, Hinkelmann B, Niemz J, Lehr C M, Jansch L, Huehn J, Alm R, Savitski M, Welte T, Hesterkamp T, Sattler M, Winterhalter M, Blankenfeldt W, Medina E, Bilitewski U, Dinkel K and Bronstrup M. Cell Host Microbe. 2025; 33 (4): 560-572 e521. doi: 10.1016/j.chom.2025.03.006

The P2X7R-antagonist AFC-5128 ameliorates chronic experimental autoimmune encephalomyelitis in a preventive and therapeutic paradigm

Hoffrogge R, Karachunskaya A, Heitmann N, Pedreiturria X, Kloster K, Bader V, Winklhofer K F, Hamacher M, Klebl B, Gold R, Dinkel K, Kleiter I and Faissner S. Front Immunol. 2025; 16 1554999. doi: 10.3389/fimmu.2025.1554999

Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach

Cherukupalli S, Degenhart C, Habenberger P, Unger A, Eickhoff J, Hoff B H and Sundby E. Pharmaceuticals. 2025; 18 (6): doi: 10.3390/ph18060814

RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma

Egea-Rodriguez S, Varaljai R, Nordmann T M, Lubis R, Philip M, Rambow F, Roesch A, Flaig M, Horn S, Stoll R, Zhao F, Paschen A, Klebl B, Hickson I D, Schadendorf D, Mann M and Helfrich I. Clin Transl Med. 2025; 15 (1): e70094. doi: 10.1002/ctm2.70094

P2X7R antagonism suppresses long-lasting hyperexcitability following traumatic brain injury in mice

Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, Mitra M, Fernandez Martin A, Menendez Mendez A, Wang Y, Ryzwesky Strogulsky N, Sun M, Melia C, Conte G, Plaza-Garcia S, Khalin I, Teng X, Plesnila N, Klebl B, Dinkel K, Hamacher M, Bhattarcharya A, Ceusters M, Palmer J, Loane D, Llop J, Henshall D and Engel T. Theranostics. 2025; 15 (4): 1399-1419. doi: 10.7150/thno.97254

2013

Stabilization of physical RAF/14-3-3 interaction by Cotylenin A as treatment strategy for RAS mutant cancers

Molzan M, Kasper S, Roglin L, Skwarczynska M, Sassa T, Inoue T, Breitenbuecher F, Ohkanda J, Kato N, Schuler M, Ottmann C. ACS Chem Biol. 2013; 8 (9): 1869-1875. doi: 10.1021/cb4003464

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker C F, Zerweck J, Schutkowski M, Steegborn C. Nat Commun. 2013; 4 2327. doi: 10.1038/ncomms3327

Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound Design

Richters A, Ketzer J, Getlik M, Grutter C, Schneider R, Heuckmann J M, Heynck S, Sos M L, Gupta A, Unger A, Schultz-Fademrecht C, Thomas R K, Bauer S, Rauh D. J Med Chem. 2013; 56 (14): 5757-5772. doi: 10.1021/jm4004076

Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat

Manley N C, Caso J R, Works M G, Cutler A B, Zemlyak I, Sun G, Munhoz C D, Chang S, Sorrells S F, Ermini F V, Decker J H, Bertrand A A, Dinkel K M, Steinberg G K, Sapolsky R M. PLoS One. 2013; 8 (4): e61789. doi: 10.1371/journal.pone.0061789

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

Reinhardt P, Schmid B, Burbulla L F, Schondorf D C, Wagner L, Glatza M, Hoing S, Hargus G, Heck S A, Dhingra A, Wu G, Muller S, Brockmann K, Kluba T, Maisel M, Kruger R, Berg D, Tsytsyura Y, Thiel C S, Psathaki O E, Klingauf J, Kuhlmann T, Klewin M, Muller H, Gasser T, Scholer H R, Sterneckert J. Cell Stem Cell. 2013; 12 (3): 354-367. doi: 10.1016/j.stem.2013.01.008

Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface

De Vries-van Leeuwen I J, da Costa Pereira D, Flach K D, Piersma S R, Haase C, Bier D, Yalcin Z, Michalides R, Feenstra K A, Jimenez C R, de Greef T F, Brunsveld L, Ottmann C, Zwart W, de Boer A H. Proc Natl Acad Sci U S A. 2013; 110 (22): 8894-8899. doi: 10.1073/pnas.1220809110

Activation of NF-κB signalling by fusicoccin-induced dimerization

Skwarczynska M, Molzan M, Ottmann C. Proc Natl Acad Sci U S A. 2013; 110 (5): E377-386. doi: 10.1073/pnas.1212990110

Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

Wang Y, Kirschner A, Fabian A K, Gopalakrishnan R, Kress C, Hoogeland B, Koch U, Kozany C, Bracher A, Hausch F. J Med Chem. 2013; 56 (10): 3922-3935. doi: 10.1021/jm400087k

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