Scientific Journals and Books

2021
Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice

Beamer E, Morgan J, Alves M, Méndez A M, Morris G, Zimmer B, Conte G, de Diego-Garcia L, Alarcón-Vila C, Ka Yiu Ng N, Madden S, Calzaferri F, de Los Ríos C, García A G, Hamacher M, Dinkel K, Pelegrín P, Henshall D C, Nicke A, Engel T. Br J Pharmacol. 2021 Dec 27;10.1111/bph.15785

IMI European Lead Factory – democratizing access to high-throughput screening

Jones P S, Boucharens S, McElroy S P, Morrison A, Honarnejad S, Boeckel Sv, van de Hurk H, Basting D, Hüser J, Jaroch S, Ottow E, Benningshof J, Folmer R H A, Leemhuis F, Patricia M Kramer-Verhulst P M, Nies V J M, Orrling K M, Rijnders T, Pfander C, Engkvist O, Pairaudeau G, Simpson P B, Ortholand J-Y, Roche D, Dömling A, Kühnert S M, Roevens P W M, van Vlijmen H, van Wanrooij E J A , Verbruggen C, Nussbaumer P, Ovaa H, van der Stelt M, Baek Simonsen K B, Tagmose L, Waldmann H, Duffy J, Finsinger D, Jurzak M, Burgess-Brown N A, Lee W H, Rutjes F P J T, Haag H, Kallus C, Mors H, Dorval T, Lesur B, Olayo F R, Hamza D, Jones G, Pearce C, Piechot A, Tzalis D, Clausen M H, Davis J, Derouane D, Vermeiren C, Kaiser M, Stockman R A, Barrault D V, Pannifer A D, Swedlow J R, Nelson A S, Orru R V A, Ruijter E, van Helden S P, Li V M, Vries T, de Vlieger J S B. Nat Rev Drug Discov. 2021 Dec 14;10.1038/d41573-021-00196-3.

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

Beamer E, Morgan J, Alves M, Menendez Mendez M, Morris G, Zimmer B, Conte G, de Diego-Garcia L, Ka Yiu Ng N, Madden S, Calzaferri F, de los Rios C, Garcia A, Hamacher M, Dinkel K, Pelegrin P, Henshall D, Nicke A, Engel T. Authorea. 2021 Sep 25;

Sequence-Selective Covalent CaaX-Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling

Franz M, Mörchen B, Degenhart C, Gülden D, Shkura O, Wolters D, Koch U, Klebl B, Stoll R, Helfrich I, Scherkenbeck J. ChemMedChem. 2021 Aug 19;16(16):2504-2514.

Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt.

Meijer FA, Saris AOWM, Doveston RG, Oerlemans GJM, de Vries RMJM, Somsen BA, Unger A, Klebl B, Ottmann C, Cossar PJ, Brunsveld L. J Med Chem. 2021 Jul 8;64(13):9238-9258.

Sequence-Selective Covalent CaaX-Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling

Franz M, Möhrchen B, Degenhart C, Gülden D, Shkura O, Wolters D, Koch, Klebl B, Stoll R, Helfrich I, Scherkenbeck J. ChemMedChem. 2021 Aug 19;16(16):2504-2514. doi: 10.1002/cmdc.202100167. Epub 2021 May 19.

Combinatorial Drug Treatments Reveal Promising Anticytomegaloviral Profiles for Clinically Relevant Pharmaceutical Kinase Inhibitors (PKIs)

Wild M, Kicuntod J, Seyler L, Wangen C, Bertzbach LD, Conradie AM, Kaufer BB, Wagner S, Michel D, Eickhoff J, Tsogoeva SB, Bäuerle T, Hahn F, Marschall M. Combinatorial Drug Treatments Reveal Promising Anticytomegaloviral Profiles for Clinically Relevant Pharmaceutical Kinase Inhibitors (PKIs). Int J Mol Sci. 2021 Jan 8;22(2):E575.

2013
An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

Rauh D., Fischer F., Gertz M., Lakshminarasimhan M., Bergbrede T., Aladini F., Kambach C., Becker CF., Zerweck J., Schutkowski M., Steegborn C.

Nat Commun. 2013 Sep 2;4:2327. doi: 10.1038/ncomms3327

Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound Design

Richters A., Ketzer J., Getlik M., Grütter C., Schneider R., Heuckmann JM., Heynck S., Sos ML., Gupta A., Unger A., Schultz-Fademrecht C., Thomas RK., Bauer S., Rauh D.

J Med Chem. 2013 Jul 10

Stabilization of physical RAF/14-3-3 interaction by Cotylenin A as treatment strategy for RAS mutant cancers

Molzan M., Kasper S., Röglin L., Skwarczynska M., Sassa T., Inoue T., Breitenbuecher F., Ohkanda J., Kato N., Schuler M., Ottmann C.

ACS Chem Biol. 2013 Jul 5

Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface

De Vries-van Leeuwen IJ, da Costa Pereira D, Flach KD, Piersma SR, Haase C, Bier D, Yalcin Z, Michalides R, Feenstra KA, Jiménez CR, de Greef TF,Brunsveld L, Ottmann C, Zwart W, de Boer AH

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8894-9. doi: 10.1073/pnas.1220809110. Epub 2013 May 15

Cheminformatics at the interface of medicinal chemistry and proteomics

Koch U., Hamacher M., Nussbaumer P.

Biochimica et Biophysica Acta 2013; May 21. pii: S1570-9639(13)00207-0. doi: 10.1016/j.bbapap.2013.05.010

Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat

Manley NC., Caso JR., Works MG., Cutler AB., Zemlyak I., Sun G., Munhoz CD., Chang S., Sorrells SF., Ermini FV., Decker JH., Bertrand AA., Dinkel K., Steinberg GK., Sapolsky RM.

PLoS One. 2013 Apr 16;8(4)

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

Peter Reinhardt, Benjamin Schmid, Lena F. Burbulla, David C. Schöndorf, Lydia Wagner, Michael Glatza, Susanne Höing, Gunnar Hargus, Susanna A. Heck, Ashutosh Dhingra, Guangming Wu, Stephan Müller, Kathrin Brockmann, Torsten Kluba, Martina Maisel, Rejko Krüger, Daniela Berg, Yaroslav Tsytsyura, Cora S. Thiel, Olympia-Ekaterini Psathaki, Jürgen Klingauf, Tanja Kuhlmann, Marlene Klewin, Heiko Müller, Thomas Gasser, Hans R. Schöler, Jared Sterneckert

Cell Stem Cell – 7 March 2013 (Vol. 12, Issue 3, pp. 354-367)

Activation of NF-κB signalling by fusicoccin-induced dimerization

Skwarczynska M., Molzan M., Ottmann C.

Proc Natl Acad Sci USA. 2013 Jan 29;110 (5):E377-86. doi: 10.1073/pnas.1212990110

Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

Wang Y., Kirschner A., Fabian AK., Gopalakrishnan R., Kress C., Hoogeland B., Koch, U., Kozany C., Bracher A., Hausch F.

Med Chem. 2013; 56(10), pp 3922-35