Scientific Journals and Books

2023

Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target

Tillmanns J, Hage S, Borst E M, Wardin J, Eickhoff J, Klebl B, Wagner S, Wangen C, Hahn F, Socher E, Marschall M. Cells. 2023; 12 (8): doi: 10.3390/cells12081162

Cytomegalovirus Cyclin-Dependent Kinase Ortholog Vcdk/Pul97 Undergoes Regulatory Interaction with Human Cyclin H and Cdk7 to Codetermine Viral Replication Efficiency

Schutz M, Wangen C, Sommerer M, Kogler M, Eickhoff J, Degenhart C, Klebl B, Naing Z, Egilmezer E, Hamilton S T, Rawlinson W D, Sticht H, Marschall M. Virus Res. 2023; 335 199200. doi: 10.1016/j.virusres.2023.199200

Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate

Sagurna L, Heinrich S, Kaufmann L S, Ruckert-Reed C, Busche T, Wolf A, Eickhoff J, Klebl B, Kalinowski J, Bandow J E. Antibiotics (Basel). 2023; 12 (7): doi: 10.3390/antibiotics12071116

A Reinvestigation of the Role of the Sorbic Acid Tail on the Antibacterial and Anti-Tuberculosis Properties of Moiramide B

Kollmorgen I, Bachmann N, Dal Molin M, Degenhart C, Zent E, Pareek V, Koch U, Rybniker J, Metzler-Nolte N, Stoll R, Klebl B, Bandow J E, Scherkenbeck J. ChemMedChem. 2023; 18 (11): e202200631. doi: 10.1002/cmdc.202200631

Functional Expression of the Atp-Gated P2x7 Receptor in Human Ipsc-Derived Astrocytes

Kesavan J, Watters O, de Diego-Garcia L, Mendez A M, Alves M, Dinkel K, Hamacher M, Prehn J H M, Henshall D C, Engel T. Purinergic Signal. 2023; doi: 10.1007/s11302-023-09957-8

Inhibiting the Glycerophosphodiesterase Edi3 in Er-Her2+ Breast Cancer Cells Resistant to Her2-Targeted Therapy Reduces Viability and Tumour Growth

Keller M, Rohlf K, Glotzbach A, Leonhardt G, Luke S, Derksen K, Demirci O, Gocener D, AlWahsh M, Lambert J, Lindskog C, Schmidt M, Brenner W, Baumann M, Zent E, Zischinsky M L, Hellwig B, Madjar K, Rahnenfuhrer J, Overbeck N, Reinders J, Cadenas C, Hengstler J G, Edlund K, Marchan R. J Exp Clin Cancer Res. 2023; 42 (1): 25. doi: 10.1186/s13046-022-02578-w

Ifn-α Primes Cancer Cells for Fusicoccin-Induced Cell Death Via 14-3-3 Ppi Stabilization

Andlovic B, Heilmann G, Ninck S, Andrei S A, Centorrino F, Higuchi Y, Kato N, Brunsveld L, Arkin M, Menninger S, Choidas A, Wolf A, Klebl B, Kaschani F, Kaiser M, Eickhoff J, Ottmann C. Cell Chem Biol. 2023; 30 (6): 573-590 e576. doi: 10.1016/j.chembiol.2023.04.005

Negishi Cross‐Coupling in the Preparation of Benzyl Substituted Pyrrolo[2,3‐D]Pyrimidine Based Csf1r Inhibitors

Aarjus T I, Teksum V, Unger A, Habenberger P, Wolf A, Eickhoff J, Klebl B, Wolowczyk C, Bjorkoy G, Sundby E, Hoff B H. European Journal of Organic Chemistry. 2023; 26 (12): 93-104. doi: 10.1002/ejoc.202300052

A Highly Selective Purine-Based Inhibitor of Csf1r Potently Inhibits Osteoclast Differentiation

Aarhus T I, Eickhoff J, Klebl B, Unger A, Boros J, Choidas A, Zischinsky M L, Wolowczyk C, Bjorkoy G, Sundby E, Hoff B H. Eur J Med Chem. 2023b; 255 115344. doi: 10.1016/j.ejmech.2023.115344

Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form

Aarhus TI, Bjornstad F, Wolowczyk C, Larsen KU, Rognstad L., Leithaug T., Unger A., Habenberger P, Wolf A, Bjorkoy G, Pridans C, Eickhoff J, Klebl B, Hoff BH, Sundby E. J Med Chem. 2023 May 25; 66(10), 6959-6980. doi: 10.1021/acs.jmedchem.3c00428.

2013

Stabilization of physical RAF/14-3-3 interaction by Cotylenin A as treatment strategy for RAS mutant cancers

Molzan M, Kasper S, Roglin L, Skwarczynska M, Sassa T, Inoue T, Breitenbuecher F, Ohkanda J, Kato N, Schuler M, Ottmann C. ACS Chem Biol. 2013; 8 (9): 1869-1875. doi: 10.1021/cb4003464

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker C F, Zerweck J, Schutkowski M, Steegborn C. Nat Commun. 2013; 4 2327. doi: 10.1038/ncomms3327

Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound Design

Richters A, Ketzer J, Getlik M, Grutter C, Schneider R, Heuckmann J M, Heynck S, Sos M L, Gupta A, Unger A, Schultz-Fademrecht C, Thomas R K, Bauer S, Rauh D. J Med Chem. 2013; 56 (14): 5757-5772. doi: 10.1021/jm4004076

Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat

Manley N C, Caso J R, Works M G, Cutler A B, Zemlyak I, Sun G, Munhoz C D, Chang S, Sorrells S F, Ermini F V, Decker J H, Bertrand A A, Dinkel K M, Steinberg G K, Sapolsky R M. PLoS One. 2013; 8 (4): e61789. doi: 10.1371/journal.pone.0061789

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

Reinhardt P, Schmid B, Burbulla L F, Schondorf D C, Wagner L, Glatza M, Hoing S, Hargus G, Heck S A, Dhingra A, Wu G, Muller S, Brockmann K, Kluba T, Maisel M, Kruger R, Berg D, Tsytsyura Y, Thiel C S, Psathaki O E, Klingauf J, Kuhlmann T, Klewin M, Muller H, Gasser T, Scholer H R, Sterneckert J. Cell Stem Cell. 2013; 12 (3): 354-367. doi: 10.1016/j.stem.2013.01.008

Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface

De Vries-van Leeuwen I J, da Costa Pereira D, Flach K D, Piersma S R, Haase C, Bier D, Yalcin Z, Michalides R, Feenstra K A, Jimenez C R, de Greef T F, Brunsveld L, Ottmann C, Zwart W, de Boer A H. Proc Natl Acad Sci U S A. 2013; 110 (22): 8894-8899. doi: 10.1073/pnas.1220809110

Activation of NF-κB signalling by fusicoccin-induced dimerization

Skwarczynska M, Molzan M, Ottmann C. Proc Natl Acad Sci U S A. 2013; 110 (5): E377-386. doi: 10.1073/pnas.1212990110

Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

Wang Y, Kirschner A, Fabian A K, Gopalakrishnan R, Kress C, Hoogeland B, Koch U, Kozany C, Bracher A, Hausch F. J Med Chem. 2013; 56 (10): 3922-3935. doi: 10.1021/jm400087k

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