Scientific Journals and Books

2023

Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target

Tillmanns J, Hage S, Borst E M, Wardin J, Eickhoff J, Klebl B, Wagner S, Wangen C, Hahn F, Socher E, Marschall M. Cells. 2023; 12 (8): doi: 10.3390/cells12081162

Cytomegalovirus Cyclin-Dependent Kinase Ortholog Vcdk/Pul97 Undergoes Regulatory Interaction with Human Cyclin H and Cdk7 to Codetermine Viral Replication Efficiency

Schutz M, Wangen C, Sommerer M, Kogler M, Eickhoff J, Degenhart C, Klebl B, Naing Z, Egilmezer E, Hamilton S T, Rawlinson W D, Sticht H, Marschall M. Virus Res. 2023; 335 199200. doi: 10.1016/j.virusres.2023.199200

Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate

Sagurna L, Heinrich S, Kaufmann L S, Ruckert-Reed C, Busche T, Wolf A, Eickhoff J, Klebl B, Kalinowski J, Bandow J E. Antibiotics (Basel). 2023; 12 (7): doi: 10.3390/antibiotics12071116

A Reinvestigation of the Role of the Sorbic Acid Tail on the Antibacterial and Anti-Tuberculosis Properties of Moiramide B

Kollmorgen I, Bachmann N, Dal Molin M, Degenhart C, Zent E, Pareek V, Koch U, Rybniker J, Metzler-Nolte N, Stoll R, Klebl B, Bandow J E, Scherkenbeck J. ChemMedChem. 2023; 18 (11): e202200631. doi: 10.1002/cmdc.202200631

Functional Expression of the Atp-Gated P2x7 Receptor in Human Ipsc-Derived Astrocytes

Kesavan J, Watters O, de Diego-Garcia L, Mendez A M, Alves M, Dinkel K, Hamacher M, Prehn J H M, Henshall D C, Engel T. Purinergic Signal. 2023; doi: 10.1007/s11302-023-09957-8

Inhibiting the Glycerophosphodiesterase Edi3 in Er-Her2+ Breast Cancer Cells Resistant to Her2-Targeted Therapy Reduces Viability and Tumour Growth

Keller M, Rohlf K, Glotzbach A, Leonhardt G, Luke S, Derksen K, Demirci O, Gocener D, AlWahsh M, Lambert J, Lindskog C, Schmidt M, Brenner W, Baumann M, Zent E, Zischinsky M L, Hellwig B, Madjar K, Rahnenfuhrer J, Overbeck N, Reinders J, Cadenas C, Hengstler J G, Edlund K, Marchan R. J Exp Clin Cancer Res. 2023; 42 (1): 25. doi: 10.1186/s13046-022-02578-w

Ifn-α Primes Cancer Cells for Fusicoccin-Induced Cell Death Via 14-3-3 Ppi Stabilization

Andlovic B, Heilmann G, Ninck S, Andrei S A, Centorrino F, Higuchi Y, Kato N, Brunsveld L, Arkin M, Menninger S, Choidas A, Wolf A, Klebl B, Kaschani F, Kaiser M, Eickhoff J, Ottmann C. Cell Chem Biol. 2023; 30 (6): 573-590 e576. doi: 10.1016/j.chembiol.2023.04.005

Negishi Cross‐Coupling in the Preparation of Benzyl Substituted Pyrrolo[2,3‐D]Pyrimidine Based Csf1r Inhibitors

Aarjus T I, Teksum V, Unger A, Habenberger P, Wolf A, Eickhoff J, Klebl B, Wolowczyk C, Bjorkoy G, Sundby E, Hoff B H. European Journal of Organic Chemistry. 2023; 26 (12): 93-104. doi: 10.1002/ejoc.202300052

A Highly Selective Purine-Based Inhibitor of Csf1r Potently Inhibits Osteoclast Differentiation

Aarhus T I, Eickhoff J, Klebl B, Unger A, Boros J, Choidas A, Zischinsky M L, Wolowczyk C, Bjorkoy G, Sundby E, Hoff B H. Eur J Med Chem. 2023b; 255 115344. doi: 10.1016/j.ejmech.2023.115344

Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form

Aarhus TI, Bjornstad F, Wolowczyk C, Larsen KU, Rognstad L., Leithaug T., Unger A., Habenberger P, Wolf A, Bjorkoy G, Pridans C, Eickhoff J, Klebl B, Hoff BH, Sundby E. J Med Chem. 2023 May 25; 66(10), 6959-6980. doi: 10.1021/acs.jmedchem.3c00428.

2011

Natural product-inspired cascade synthesis yields modulators of centrosome integrity

Duckert H, Pries V, Khedkar V, Menninger S, Bruss H, Bird A W, Maliga Z, Brockmeyer A, Janning P, Hyman A, Grimme S, Schurmann M, Preut H, Hubel K, Ziegler S, Kumar K, Waldmann H. Nat Chem Biol. 2011; 8 (2): 179-184. doi: 10.1038/nchembio.758

Recruitment of cyclin-dependent kinase 9 to nuclear compartments during cytomegalovirus late replication: importance of an interaction between viral pUL69 and cyclin T1

Feichtinger S, Stamminger T, Muller R, Graf L, Klebl B, Eickhoff J, Marschall M. J Gen Virol. 2011; 92 (Pt 7): 1519-1531. doi: 10.1099/vir.0.030494-0

Structure-guided development of selective RabGGTase inhibitors

Bon R S, Guo Z, Stigter E A, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody R S, Waldmann H. Angew Chem Int Ed Engl. 2011; 50 (21): 4957-4961. doi: 10.1002/anie.201101210

Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile

Radtke L, Willot M, Sun H, Ziegler S, Sauerland S, Strohmann C, Frohlich R, Habenberger P, Waldmann H, Christmann M. Angew Chem Int Ed Engl. 2011; 50 (17): 3998-4002. doi: 10.1002/anie.201007790

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6Hindolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay A C, Conte I, Ercolani C, Zaramella S, Palumbi M C, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M. J Med Chem. 2011; 54 (1): 289-301. doi: 10.1021/jm1013105

Protein Kinases as Drug Targets: 49 (Methods and Principles in Medicinal Chemistry)

Klebl B, Müller G, Hamacher M, Mannhold R, Kubinyi H, Folkers G. 2011. 1 ed. ‎ Wiley-VCH Verlag GmbH & Co. KGaA.

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