Scientific Journals and Books

2026

Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1

Krings K S, Hatzfeld J, Weller S, Borkowski N, Llewellyn T R, Schmitt L, Scherer B, Itkonen H M, Peter C, Stork B, Geyh S, Eickhoff J, Klebl B, Qin N, Essmann F and Wesselborg S. Cell Death Dis. 2026; 17 (1): doi: 10.1038/s41419-026-08889-6

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor alpha-Hemolysin by Blocking the Pullout of Its Stem Domain

Korotkov V S, Lukat P, Di Lucrezia R, Shekhar A, Degenhart C, Diestel R, Bilitewski U, Dinkel K, Blankenfeldt W and Bronstrup M. ChemMedChem. 2026; 21 (4): e202501098. doi: 10.1002/cmdc.202501098

Reducing PI4KIIIalpha Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical Neurons

Clemente E, Sivasubramanian R, Kordes S, Bhatia P, Hans R, Vogel S, Baumann M, Klebl B and Sterneckert J. Cells. 2026; 15 (13): doi: 10.3390/cells15131228

Towards selective peptide deformylase inhibitors: A mass spectrometry-based evaluation of in cellulo activity of actinonin and bromoindole derivatives

Bachmann N, Schultz A, Zouatom M, Zhou T, Degenhart C, Koch U, Schakermann S, Huning J, Heinrich S, Dal Molin M, Zischinsky M L, Tourel S, Klebl A K, Rybniker J, Klebl B M, Scherkenbeck J and Bandow J E. Eur J Med Chem. 2026; 308 118678. doi: 10.1016/j.ejmech.2026.118678

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics

Al Kabbani M A, Jatoo P, Klebl A K, Klebl B and Zempel H. PLoS One. 2026; 21 (3): e0339922. doi: 10.1371/journal.pone.0339922

2016

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

Jimenez-Pacheco A, Diaz-Hernandez M, Arribas-Blazquez M, Sanz-Rodriguez A, Olivos-Ore L A, Artalejo A R, Alves M, Letavic M, Miras-Portugal M T, Conroy R M, Delanty N, Farrell M A, O'Brien D F, Bhattacharya A, Engel T, Henshall D C. J Neurosci. 2016; 36 (22): 5920-5932. doi: 10.1523/JNEUROSCI.4009-15.2016

Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold

Škopić M K, Bugain O, Jung K, Onstein S, Brandherm S, Kalliokoski T, Brunschweiger A. MedChemComm. 2016; 7 (10): 1957-1965. doi: 10.1039/c6md00243a

Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics

Chakedis J, French R, Babicky M, Jaquish D, Mose E, Cheng P, Holman P, Howard H, Miyamoto J, Porras P, Walterscheid Z, Schultz-Fademrecht C, Esdar C, Schadt O, Eickhoff J, Lowy A M. Oncotarget. 2016; 7 (29): 45959-45975. doi: 10.18632/oncotarget.10009

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

Fischer W, Franke H, Krugel U, Muller H, Dinkel K, Lord B, Letavic M A, Henshall D C, Engel T. PLoS One. 2016; 11 (6): e0156468. doi: 10.1371/journal.pone.0156468

Identification of pyrazolopyridazinones as PDEδ inhibitors

Papke B, Murarka S, Vogel H A, Martin-Gago P, Kovacevic M, Truxius D C, Fansa E K, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens P I. Nat Commun. 2016; 7 11360. doi: 10.1038/ncomms11360

The Evolving Role of the Medicinal Chemist

Lawton G, Nussbaumer P. Prog Med Chem. 2016; 55 193-226. doi: 10.1016/bs.pmch.2015.11.001

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