Press releases

Thursday November 2nd, 2023
Lead Discovery Center GmbH licenses next-generation anticancer drug candidate to HLB Life Science R&D
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Lead Discovery Center GmbH licenses next-generation anticancer drug candidate to HLB Life Science R&D
  • The new drug candidate effectively inhibits cancer cell repair by blocking RNA transcription
  • The goal is to jointly develop a new first-in-class therapeutic drug

Dortmund, Germany, and Seoul, Korea – November 2nd, 2023. HLB Life Science R&D (HLB), a leading Korean biopharmaceutical company, signed an agreement with Lead Discovery Center GmbH (LDC) to license and co-develop a next-generation anticancer drug candidate. LDC is a top-class translational research organization renowned worldwide for early-stage drug discovery. The licensed drug candidate is based on an asset largely incubated at LDC with support from the neighboring Max Planck Institute of Molecular Physiology (Dortmund, Germany).

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This first-in-class candidate showed anticancer efficacy in early-stage research. It especially inhibits the transcription of genes involved in the self-repair of damaged cancer cells. HLB will move the candidate into clinical development by quickly completing the preclinical phase together with LDC.

HLB announced on August 9th, 2023, the signature of the license agreement for exclusive rights worldwide of the drug candidate. LDC and its partners Max Planck Foundation, Max Planck Society and KHAN Technology Transfer Fund I (KHAN-I) will receive an upfront payment, remuneration for development and sales milestones, along with royalties based on future revenues.

Dr. Bert Klebl, CEO & CSO of LDC, says, “We are delighted to have found a strong partner in HLB Life Science R&D. HLB has the power to promote our promising and novel candidate to the next stages of development, with the aim to reach cancer patients as soon as possible. We are much looking forward to this cooperation and partnership”.

Dr. Yong Hae Han, CEO of HLB Life Science R&D and CTO of HLB Group, adds, “We have deeply discussed with LDC for a long time that both companies are very interested in researching and developing next-generation anticancer drugs. Finally, both partners have agreed to take such interests to the next level. As soon as we bring the candidate into our R&D center, we will focus all our efforts on this project, and strengthen our partnership with LDC.”

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Contact
Lead Discovery Center GmbH
Otto-Hahn-Straße 15
44227 Dortmund
Germany
Phone: +49 231 97 42 70 00
E-mail: pr@lead-discovery.de

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About Lead Discovery Center GmbH

Lead Discovery Center GmbH (LDC) was established in 2008 by the technology transfer organization Max Planck Innovation, as a novel approach to capitalize on the potential of excellent basic research for the discovery of new therapies for diseases with high medical need. LDC takes on promising early-stage projects from academia and transforms them into innovative pharmaceutical leads and antibodies that reach initial proof-of-concept in animals as well as candidate nomination. In close collaboration with high-profile partners from research and industry, LDC is building a strong and growing portfolio of small molecule and antibody leads with exceptional medical and commercial potential. LDC sustains a long-term partnership with the Max Planck Society and KHAN Technology Transfer Fund I (KHAN-I), and has formed alliances with AstraZeneca, Bayer, Boehringer Ingelheim, Merck KGaA, Daiichi Sankyo, Qurient, invIOs, Novo Nordisk, Cumulus Oncology, Nodus Oncology, JT Pharmaceuticals, KinSea Lead Discovery AS, and the Helmholtz Centre for Infection Research e.g. In addition, LDC also works with leading translational drug discovery centers and with various investors to provide its assets for company creation.

Further information available at: www.lead-discovery.de

About HLB Life Science R&D

HLB Life Science R&D, headquartered in Seoul, South Korea, is a 100% subsidiary of HLB Life Science, which was founded in 1998 and listed on KOSDAQ in 2008, with its current market cap of 1 billion USD approximately. Both HLB Life Science and HLB Life Science R&D are owned and governed by HLB group. HLB Group has now 37 affiliates and, especially in the healthcare industry, it has established a fully integrated bio-ecosystem from research to commercialization. As a result of such ecosystem, one of the affiliates submitted an NDA to the US FDA for a first-line therapy of Hepatocellular Carcinoma (HCC). As a core of R&D within the group, HLB Life Science R&D has been developing anticancer drugs for the best cancer treatments by strengthening partnerships worldwide and exploring opportunities for synergies with its R&D capabilities.

Further information available at: http://hlbkorea.com/en/

About KHAN-I

KHAN Technology Transfer Fund I GmbH & Co KG (KHAN-I) is an early-stage life sciences venture fund with € 70 million under management. Their mission is to create value through cooperative drug development partnerships with academic innovators in Europe. KHAN-I focuses on first-in-class therapies for attractive markets with a high unmet medical need. The fund is managed by Khanu Management GmbH, an experienced team of professionals with proven track records in early-stage drug development and academic spin-offs as well as pharma licensing and partnering. KHAN-I received an investment from the European Investment Fund (EIF) with the support of InnovFin Equity, and with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (EFSI) under the Investment Plan for Europe. KHAN-I is also supported by Austria Wirtschaftsservice GmbH (AWS with funds provided by the Austrian Federal Ministry for Digital and Economic Affairs and the Austrian Foundation for Research, Technology, and Development), Max Planck Foundation, and Thyssen’sche Handelsgesellschaft mbH. In addition, KHAN-I sustains a preferred partnership with the Max Planck Society (Max-Planck-Gesellschaft e.V.).

Further information available at: www.khanu.de

About Max Planck Foundation

The Max Planck Foundation is a private, independent and non-profit organization with the sole purpose of providing funds for excellent, innovative and forward-looking research projects of the Max Planck Society. As additional support for scientists from the Max Planck Society the Foundation also facilitates the transfer from knowledge to application. The foundation was established in 2006 and the assets of the foundation are currently around € 650 million

About Max Planck Innovation

Max Planck Innovation (MI) is responsible for the technology transfer of the Max Planck Society and, as such, the link between industry and basic research. With an interdisciplinary team, MI advises and supports scientists at Max Planck Institutes in evaluating their inventions, filing patents and founding companies. MI offers industry unique access to the innovations of the Max Planck Institutes. Thus, MI performs an important task: the transfer of basic research results into products that contribute to economic and social progress.

Further information at: www.max-planck-innovation.com.

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Wednesday October 11th, 2023
LDC and JT team up for the discovery of new therapies
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LDC and JT team up for the discovery of new therapies

Dortmund, Germany, October 11th, 2023 – The Lead Discovery Center GmbH (LDC) and Japan Tobacco Inc. (JT) have closed a collaboration agreement to discover new first-in-class therapeutic approaches, focusing around novel chemical entities for the treatment of various diseases with significant unmet medical need.

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Over a period of up to seven years, LDC, together with its extensive academic network, will identify high-potential projects that fit JT’s therapeutic priorities and in-licensing needs. The network includes research institutes of the Max Planck Society, other research organizations, as well as high-profile universities from all over Germany and beyond. Ideas for new therapeutic approaches will be collaboratively incubated at LDC as usual, although with additional support and expertise from JT. After achieving the proof-of-concept milestone by demonstrating in vivo efficacy for representatives of the respective new compound class, such projects will be targets for in-licensing by JT, where they will be further developed.

“We are pleased to team up with the LDC and its excellent network of academic inventors. The collaboration will enable us to identify truly novel therapeutic approaches that could make a meaningful difference in the lives of patients around the world”, says Muneaki Fujimoto, President of JT’s Pharmaceutical Business.

“We are excited to have a new industry partner on board who shares our brave ambition and the associated risks to transfer highly innovative approaches from academic research into application”, Bert Klebl, CEO and CSO of LDC, continues. “With their proven expertise in business and drug development, JT is perfectly positioned to advance early-stage projects along the value chain, and ultimately towards patients who urgently need new therapeutic options. We are looking forward to a productive and exciting collaboration.”

Academic inventors and their institutions will not only benefit from the drug discovery and development experience of both LDC and JT, but also from future commercialization revenues.

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Contact
Lead Discovery Center GmbH
Otto-Hahn-Straße 15
44227 Dortmund
Germany
Phone: +49 231 97 42 70 00
Mail: pr@lead-discovery.de

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About LDC

Lead Discovery Center GmbH (LDC) was established in 2008 by the technology transfer organization Max Planck Innovation, as a novel approach to capitalize on the potential of excellent basic research for the discovery of new therapies for diseases with high medical need. The LDC takes on promising early-stage projects from academia and transforms them into innovative pharmaceutical leads and antibodies that reach initial proof-of-concept in animals as well as candidate nomination. In close collaboration with high-profile partners from research and industry, the LDC is building a strong and growing portfolio of small molecule and antibody leads with exceptional medical and commercial potential.

LDC sustains a long-term partnership with the Max Planck Society and its institutes as well as with KHAN-I, and has formed alliances with AstraZeneca, Bayer, Boehringer Ingelheim, Merck KGaA, Daiichi Sankyo, Qurient, InvIOS, Novo Nordisk, Cumulus Oncology, Nodus Oncology, KinSea AS, HLB Life Science, the Helmholtz Center for Infection Research, e.g. In addition, LDC also works with leading translational drug discovery centers and with various investors to provide its assets for company creation.

Further information at www.lead-discovery.de

About JT

JT has a pharmaceutical business that focuses on research and development, manufacturing and sales of prescription drugs.

Further information at https://www.jt.com/about/division/pharma/index.html

Tuesday September 12th, 2023
RIANA Therapeutics enters into collaboration agreement with LDC
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RIANA Therapeutics enters into collaboration agreement with LDC

Vienna, Austria, and Dortmund, Germany – September 12th, 2023. RIANA Therapeutics, a spin-off from Vetmeduni Vienna has entered into a collaborative agreement with the Lead Discovery Center GmbH, a renowned organization specialized in translational drug discovery. This partnership marks the first important milestone on RIANA Therapeutics´ mission to discover and develop novel cancer therapeutics that disrupt oncogenic protein-protein interactions (PPIs).

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Inhibition of PPIs is an emerging drug modality and a highly promising therapeutic approach for numerous diseases, including cancer, to overcome widespread resistance to drugs already in use and to improve treatment efficacy. Under the now-signed collaboration agreement, LDC will conduct high-throughput screening (HTS) using a diverse compound library of more than 200,000 chemical substances to identify novel PPI inhibitors targeting STAT5, a critical mediator driving the development of Acute Myeloid Leukemia (AML).

Through the strategic partnership with LDC, RIANA Therapeutics secures invaluable access to LDC’s profound expertise in the field of early drug discovery. By combining their respective strengths, RIANA Therapeutics and LDC aim to accelerate the translation of innovative discoveries into potential therapeutics, with the declared long-term goal of improving the well-being of patients on a global scale.

Anna Orlova, co-founder and CEO of RIANA Therapeutics, expressed her excitement about the collaboration: “We are thrilled to partner with LDC, a highly experienced player in drug discovery. Their expertise and capabilities will be instrumental in our efforts to develop breakthrough therapeutics for hematopoietic and other cancer types. This collaboration marks a significant milestone for RIANA Therapeutics, and we look forward to working together to advance our shared mission of improving human health.”

Peter Nussbaumer, Managing Director at LDC, added: “We are highly motivated to start the challenging discovery of inhibitors targeting oncogenic PPI interactions within this new partnership with RIANA. This cooperation has the great potential to lay the groundwork for new, urgently needed therapeutic approaches for AML patients.”

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About LDC

Lead Discovery Center GmbH (LDC) was established in 2008 by the technology transfer organization Max Planck Innovation, as a novel approach to capitalize on the potential of excellent basic research for the discovery of new therapies for diseases with high medical need. LDC takes on promising early-stage projects from academia and transforms them into innovative pharmaceutical leads and antibodies that reach initial proof-of-concept in animals as well as candidate nomination. In close collaboration with high-profile partners from research and industry, LDC is building a strong and growing portfolio of small molecule and antibody leads with exceptional medical and commercial potential.

LDC sustains a long-term partnership with the Max Planck Society and its institutes as well as with KHAN-I, and has formed alliances with AstraZeneca, Bayer, Boehringer Ingelheim, Merck KGaA, Daiichi Sankyo, Qurient, InvIOS, Novo Nordisk, Cumulus Oncology, Nodus Oncology, JT Pharmaceuticals, KinSea AS, HLB Pharma, the Helmholtz Center for Infection Research, e.g. In addition, LDC also works with leading translational drug discovery centers and with various investors to provide its assets for company creation.

Further information at www.lead-discovery.de

About RIANA

RIANA Therapeutics was founded in February 2023 as a spin-off of Vetmeduni in Vienna by Anna Orlova, Richard Moriggl, and Oliver Szolar. The technological foundation is based on a proprietary platform technology for the discovery of compounds that target cancer-promoting protein-protein interactions (PPI), enabling a reliable search for inhibitors that block the formation of specific oncogenic PPIs. Building upon this novel proprietary technology, the team led by Orlova is working on developing new compounds specifically targeting AML, as well as other blood cancers and certain types of solid tumors.

Further information at www.rianatx.com

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Contact
Lead Discovery Center GmbH
Otto-Hahn-Straße 15
44227 Dortmund
Germany
Phone: +49 231 97 42 70 00
Mail: pr@lead-discovery.de

Wednesday February 8th, 2023
Norwegian Start-up KinSea to Exploit the Potential of Marine Bioactives for the Treatment of Cancer and other Diseases
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Norwegian Start-up KinSea to Exploit the Potential of Marine Bioactives for the Treatment of Cancer and other Diseases
  • Launched by UiT The Arctic University of Norway (UiT), University of Bergen (UiB), Norinnova, and Lead Discovery Center (LDC)
  • Lead program with outstanding in vivo efficacy as pan-mutant FLT3 kinase inhibitor in AML, even against hard-to-treat, drug-induced and drug-resistant mutations
  • Diversified drug discovery pipeline to be established based on the partners’ unique access to bioactives from the Arctic Ocean and premier drug discovery expertise
  • Financing secured by KHAN Technology Transfer Fund I
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February 8th, 2023, Tromsø and Bergen, Norway, Dortmund, Germany. Norinnova, UiT The Arctic University of Norway (UiT), the University of Bergen (UiB) and the Lead Discovery Center GmbH (LDC), launched a new spin-out company, KinSea Lead Discovery AS (KinSea), to further develop an FLT3 kinase inhibitor program at lead status based on unique chemistry from marine sources towards (pre)clinical development. In addition, KinSea in a collaboration with UiT shall continue to comprehensively exploit the potential of marine bioactives for the treatment of human diseases. Seed financing is initially secured through a convertible loan from KHAN Technology Transfer Fund I GmbH & Co KG (KHAN-I), an early-stage life sciences venture fund based in Germany, with the purpose to
expand the investor syndicate.

The company is based in Tromsø and will initially focus on its pan-mutant FMS-like tyrosine kinase 3 (FLT3) inhibitor program which has strong potential to overcome the limitations of currently available first- and second-generation FLT3 inhibitors for the treatment of acute myeloid leukemia (AML) as well as other hematologic tumors. It is founded on a proprietary scaffold based on a natural product from the Arctic Ocean that has been discovered and further developed by the founding partners. Results from in vivo proof-of-concept studies in an animal model of AML suggest superior properties over existing FLT3 inhibitors, including broad activity against known drug-induced and drug-resistant FLT3 mutations, improved selectivity, and outstanding in vivo potency. The project has been developed in collaboration between UiT, UiB, and LDC and has been funded by the Norwegian Research Council and the regional biotech program MABIT.

‘For AML patients this may translate into safer, more effective and entirely new treatment options, where other drugs fail. It is a great opportunity to exploit the potential of this program for the benefit of patients,’ says Jeanette Hammer Andersen, CEO of KinSea. ‘We are excited to continue our longstanding collaboration on marine bioprospecting and to take our FLT3 inhibitors through the next steps in the drug discovery pipeline,’ adds Bengt Erik Haug, CSO of KinSea.

Using the proceeds of the seed financing, KinSea plans to mature its lead program into a preclinical candidate ready for advanced preclinical and clinical development by licensing partners. In addition, the company will seek to use UiT’s marine bioactives repository to gradually expand its drug discovery pipeline and become a sustainable source of high-potential drug candidates based on novel scaffolds from the Arctic Ocean.

‘We are convinced there are many more treasures hidden in the Arctic Ocean that could help solve some of the most pressing challenges in human health,’ adds Bert Klebl, CEO & CSO of LDC. ‘With its premier access to marine bioactives and the distinguished drug discovery expertise of its partners, KinSea is perfectly positioned to unlock this potential.’

Dag Rune Olsen, UiT´s director: Through our research effort on marine bioprospecting, highly motivated scientists, and the longstanding fruitful collaboration with the LDC, we have created the basis for this spin-out company. It is important for UiT to contribute to new business and value creation through innovation based on excellent research’.

‘The faculty of Mathematics and Natural Sciences sees the KinSea start-up as a very positive outcome of the longstanding high-level research that is being conducted at the faculty. Providing new knowledge and facilitating for innovation based on research is at the heart of the faculty´s mission. Together with a skilled team of partners we aim to fulfill the translation from basic research to a socially beneficial innovation project’, states Gunn Mangerud, UiB´s Dean of the Faculty of Mathematics and Natural Sciences.

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About UiT
UiT The Arctic University of Norway (UiT) is the northernmost university of the world. Its location on the edge of the Arctic implies a mission. The Arctic is of increasing global importance. Climate change, the exploitation of Arctic resources and environmental threats are topics of great public concern, which UiT situated in all of Northern Norway take special interest in. At UiT The Arctic University of Norway we explore global issues from a close-up perspective.

About UiB
The University of Bergen (UiB) is an internationally recognised research university. Academic diversity and high quality are fundamental for us, as we aim is to develop knowledge that shapes society. UiB is the most cited university in Norway and we are among the very best in the world at interacting and collaborating internationally, and with actors outside the university. Situated in the Ocean City of Bergen, UiB has been assigned a leading role on the work with Sustainable Development Goal 14 Life Below Water.

About Norinnova
Norinnova is one of Northern Norway’s most competent and experienced agencies for research commercialization. Norinnova connects researchers, start-up environments, companies and commercial actors to develop and utilize the region’s innovation power. For more than 30 years, Norinnova has worked closely with researchers and leading research communities in Northern Norway to harness the power of innovation in the north. This collaboration has contributed to the creation of brand-new businesses and has reinforced existing companies through new products and services. Norinnova secures rights, helps provide funding, investigates market potential, finds relevant partners, and contributes so that the scientists can get their product or service to the market.
Further information at
www.norinnova.no

About LDC
Lead Discovery Center GmbH (LDC) was established in 2008 by the technology transfer organization Max Planck Innovation, as a novel approach to capitalize on the potential of excellent basic research for the discovery of new therapies for diseases with high medical need. The LDC takes on promising early-stage projects from academia and transforms them into innovative pharmaceutical leads and antibodies that reach initial proof-of-concept in animals as well as candidate nomination. In close collaboration with high-profile partners from research and industry, the LDC is building a strong and growing portfolio of small molecule and antibody leads with exceptional medical and commercial potential. LDC sustains a long-term partnership with the Max Planck Society and KHAN-I, and has formed alliances with AstraZeneca, Bayer, Boehringer Ingelheim, Merck KGaA, Daiichi Sankyo, Qurient, Roche, InvIOs, e.g. In addition, LDC also works with leading translational drug  discovery centers and with various investors to provide its assets for company creation.
Further information at
www.lead-discovery.de


About KHAN-I
KHAN Technology Transfer Fund I GmbH & Co KG (KHAN-I) is an early-stage life sciences venture fund with €70 million under management. Our mission is to create value through cooperative drug development partnerships with academic innovators in Europe. KHAN-I focuses on first-in-class therapies for attractive markets with a high unmet medical need. The fund is managed by Khanu Management GmbH, an experienced team of professionals with proven track records in early-stage drug development and academic spin-offs as well as pharma licensing and partnering. KHAN-I received an investment from the European Investment Fund (EIF) with the support of InnovFin Equity, and with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (“EFSI”) under the Investment Plan for Europe. KHANI is also supported by Austria Wirtschaftsservice GmbH (AWS with funds provided by the Austrian
Federal Ministry for Digital and Economic Affairs and the Austrian Foundation for Research, Technology, and Development), Max Planck Foundation, and Thyssen’sche Handelsgesellschaft mbH. In addition, KHAN-I sustains a preferred partnership with the Max-Planck Society (Max-Planck Gesellschaft e.V.).
Further information at
www.khanu.de

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Contact
Lead Discovery Center GmbH
Otto-Hahn-Straße 15
44227 Dortmund
Germany
Phone: +49 231 97 42 70 00
Mail: pr@lead-discovery.de

Tuesday July 11th, 2017
Daiichi Sankyo, Max Planck Innovation and Lead Discovery Center Announce Cancer Research Collaboration
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Daiichi Sankyo, Max Planck Innovation and Lead Discovery Center Announce Cancer Research Collaboration

Daiichi Sankyo, Max Planck Innovation and LDC have signed an agreement providing Daiichi Sankyo with the option to receive the exclusive rights to a new lead compound for the treatment of cancer to be discovered and developed at LDC.

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Tokyo, Japan, Basking Ridge, NJ and Dortmund, Germany – (July 11, 2017) – Daiichi Sankyo Co., Limited (hereafter, Daiichi Sankyo), Max Planck Innovation GmbH and the Lead Discovery Center GmbH have signed an agreement providing Daiichi Sankyo with the option to receive the exclusive rights to a new lead compound for the treatment of cancer to be discovered and developed at the Lead Discovery Center.

This new partnership builds on biology insights in the field of transcriptional regulation from the work of Prof. Matthias Geyer at the Max Planck Institute of Molecular Physiology in Dortmund and the Research Center caesar (Center of Advanced European Studies and Research) in Bonn, Germany. Combined with the Lead Discovery Center’s strong drug discovery expertise in the design of highly selective kinase inhibitors, Daiichi Sankyo, Max Planck researchers and the Lead Discovery Center will now closely cooperate to further optimize these novel compounds that target cancer cell transcription and proliferation.

Daiichi Sankyo together with the Max Planck Society, supported by Max Planck Foundation, will jointly fund the respective drug discovery efforts at the Lead Discovery Center. Once the project has achieved proof-of-concept in relevant in vivo models, Daiichi Sankyo has the exclusive rights to license the program at pre-defined terms for subsequent preclinical and clinical development. The agreement includes an upfront payment as well as development and sales milestones plus royalties. The licensing revenues will be shared between Max Planck Society, the Lead Discovery Center and all contributing researchers and institutions

“The Lead Discovery Center is our prime partner for innovative drug discovery projects and developing novel compounds with a high therapeutic potential from the Max Planck Institutes. This agreement with Daiichi Sankyo, a recognized leader in the development and supply of innovative pharmaceutical products, again shows the high quality of research projects driven at the Max Planck laboratories. Moreover, the agreement is a great opportunity to advance the research findings into pharmaceutical development, providing potential new treatment options for patients with cancer,” according to Dr. Matthias Stein-Gerlach, patent and licensing manager at Max Planck Innovation, Max Planck Society´s technology transfer organization.

“This project collaboration and option agreement is building on the excellent experiences that Daiichi Sankyo and the Lead Discovery Center previously made from a discovery alliance that started in 2014, as well as close ties and many interactions between Daiichi Sankyo and the Max Planck Society, such as the collaboration with the Axel Ullrich lab. Max Planck Innovation has been instrumental to close this partnership,” adds Dr. Bert Klebl, Managing Director and CSO at the Lead Discovery Center.

“It is a great pleasure for us to start this research collaboration with Max Planck Innovation and the Lead Discovery Center to further generate innovation for our cancer drug discovery efforts,” said Antoine Yver, MD, MSc, Executive Vice President and Global Head of Oncology Research and Development, Daiichi Sankyo. “We are excited about the integration of Max Planck Society’s high quality science and the Lead Discovery Center’s expertise in lead discovery into Daiichi Sankyo’s drug research and development platform.”
Daiichi Sankyo, the Lead Discovery Center and the Max Planck Society aim to further expand their collaboration into additional programs in the future.

About Max Planck Innovation
Max Planck Innovation is responsible for the technology transfer of the Max Planck Society and, as such, serves as a link between industry and basic research. With its interdisciplinary team it advises and supports scientists in evaluating their inventions, filing patents, and founding companies. Max Planck Innovation offers the industry unique access to the innovations of the Max Planck Institutes, and therefore performs an important task: the transfer of basic research results into products, which contributes to economic and social progress.

For more information, please visit: www.max-planck-innovation.de

About Daiichi Sankyo Cancer Enterprise
The vision of Daiichi Sankyo Cancer Enterprise is to leverage our world-class, innovative science and push beyond traditional thinking in order to create meaningful treatments for patients with cancer. We are dedicated to transforming science into value for patients, and this sense of obligation informs everything we do. Anchored by our Antibody Drug Conjugate (ADC) and Acute Myeloid Leukemia (AML) Franchises, our cancer pipeline includes more than 20 small molecules, monoclonal antibodies and ADCs stemming from our powerful research engines: our two laboratories for biologic/immuno-oncology and small molecules in Japan, and Plexxikon Inc., our small molecule structure-guided R&D center in Berkeley, CA.

For more information, please visit: www.DSCancerEnterprise.com

About Daiichi Sankyo
Daiichi Sankyo Group is dedicated to the creation and supply of innovative pharmaceutical products to address diversified, unmet medical needs of patients in both mature and emerging markets. With over 100 years of scientific expertise and a presence in more than 20 countries, Daiichi Sankyo and its 15,000 employees around the world draw upon a rich legacy of innovation and a robust pipeline of promising new medicines to help people. In addition to a strong portfolio of medicines for hypertension and thrombotic disorders, under the Group’s 2025 Vision to become a “Global Pharma Innovator with a Competitive Advantage in Oncology,” Daiichi Sankyo research and development is primarily focused on bringing forth novel therapies in oncology, including immuno-oncology, with additional focus on new horizon areas, such as pain management, neurodegenerative diseases, heart and kidney diseases, and other rare diseases. For more information, please visit: www.daiichisankyo.com.  Daiichi Sankyo, Inc. headquartered in Basking Ridge, New Jersey, is a member of the Daiichi Sankyo Group.

 

For more information, please visit: www.dsi.com

Tuesday April 11th, 2017
LDC and SOTIO Enter License and Collaboration Agreement for First-in-class Cancer Metabolism Program
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LDC and SOTIO Enter License and Collaboration Agreement for First-in-class Cancer Metabolism Program

The Lead Discovery Center GmbH (LDC), Max Planck Innovation GmbH (MI) and SOTIO a.s. have signed a collaboration and license agreement providing SOTIO with exclusive rights to an oncology program addressing a novel target in tumor metabolism. It was discovered at the Max Planck Institute for Biology of Ageing and jointly advanced by the LDC and Max Planck scientists into drug discovery.

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Dortmund, Germany and Prague, Czech Republic, April 11, 2017 – The Lead Discovery Center GmbH (LDC), Max Planck Innovation GmbH (MI) and SOTIO a.s. have signed a collaboration and license agreement providing SOTIO with exclusive rights to an oncology program addressing a novel target in tumor metabolism. It was discovered at the Max Planck Institute for Biology of Ageing and jointly advanced by the LDC and Max Planck scientists into drug discovery.
Under the terms of the agreement, the LDC and its academic partners will perform further lead optimization and identify corresponding biomarkers for the program in collaboration with SOTIO. Upon nomination of a pre-clinical candidate, SOTIO will be responsible for the preclinical and clinical development as well as subsequent marketing and commercialization.
The LDC is eligible to receive research funding from SOTIO as well as upfront, development and sales milestone payments plus royalties on net sales of the product. Any revenues received by the LDC will be shared with the academic inventors, the Max Planck Institute for Biology of Ageing and the Max Planck Society. Financial details were not disclosed.
“We are excited to collaborate with SOTIO”, said Dr Bert Klebl, CEO of the LDC. “The team at SOTIO combines strong, global development expertise with the dynamic spirit of a mid-sized innovation leader. This makes them an ideal partner for translating the results of our collaborative efforts with the Max Planck team into novel therapies. Together we have investigated and developed a completely new molecular mechanism for the potential future therapy of cancer patients. With SOTIO on board, we are perfectly positioned to progress this new drug candidate to patients as fast as possible.”

Ladislav Bartonicek, CEO of SOTIO said, “Targeting cancer metabolism is a highly attractive and innovative approach for the treatment of cancer. Based on the world-class research at Max Planck, the team at LDC has generated very interesting lead candidates on this first-in-class cancer metabolism program with a promising safety and efficacy profile. We very much look forward to our collaboration with Max Planck and the LDC.”

About SOTIO

SOTIO is an international biotechnology company leading the efforts of PPF Group to build a diverse biotechnology portfolio through its own research & development, collaborations, in-licensing, investments, mergers and acquisitions. The company is developing new medical therapies, focusing on the treatment of cancer and autoimmune diseases. The most advanced project is its proprietary platform of active cellular immunotherapy (ACI) based on dendritic cells. SOTIO is conducting multiple Phase I to Phase III clinical trials verifying the safety and efficacy of its DCVAC products. SOTIO is also collaborating with NBE Therapeutics on the development of novel antibody-drug conjugate products (ADC) and with Cytune Pharma on developing novel IL15-based immunotherapies for the treatment of cancer. SOTIO has facilities in Europe, the United States, China and Russia.

Further information at: www.sotio.com

Contact

Richard Kapsa
Head of Communications
T. +420 603 280 971
E. kapsa@sotio.com
SOTIO a.s.
Jankovcova 1518/2
170 00 Prague
Czech Republic

Monday March 20th, 2017
Arix Bioscience plc, LDC and University of Leeds collaborate to develop novel therapeutics for metabolic diseases First project from LDC's agreement with Arix
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Arix Bioscience plc, LDC and University of Leeds collaborate to develop novel therapeutics for metabolic diseases First project from LDC's agreement with Arix

Arix Bioscience plc (LSE:ARIX), a global healthcare and life science company supporting medical innovation, has signed an agreement with the Lead Discovery Center, Max Planck Innovation, and the University of Leeds to develop new therapeutics for metabolic diseases based on the discoveries from these organisations.

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First project from Arix’s agreement with LDC

LONDON, 20 MARCH 2017: Arix Bioscience plc (LSE:ARIX) (“Arix Bioscience” or “the Company”), a global healthcare and life science company supporting medical innovation, has signed an agreement with the Lead Discovery Center GmbH (LDC), Max Planck Innovation GmbH (MI), and the University of Leeds to develop new therapeutics for metabolic diseases based on the discoveries from these organisations.

Under the terms of the agreement, Arix Bioscience will fund and manage experimental work that builds on fundamental discoveries from the faculty of cardiovascular medicine and diabetes at the University of Leeds and LDC, focusing on the development of antagonists of a novel target for a variety of metabolic indications.

LDC, established by Max Planck Innovation and the Max Planck Society to capitalise on the potential of research from Max Planck Institutes, takes basic pathobiology or novel targets from academia and uses its integrated drug discovery platform to produce new candidate therapies for development.

This collaboration originated from a strategic agreement signed between Arix Bioscience and LDC in 2016, under which the LDC shares pipeline projects with Arix Bioscience. This is the first project to arise from this agreement.

Joe Anderson, Chief Executive Officer of Arix Bioscience, commented: “Arix Bioscience aims to identify the best innovation in healthcare and life science and to use our permanent capital approach and strategic insight to support scientific teams in converting this innovation into proprietary development projects.

“We recently raised £100m in an initial public offering on the London Stock Exchange from a range of high quality investors who are supportive of our strategy and enthusiastic about our pipeline. We believe the combination of capital and strategic guidance we can offer can have a transformative impact on early-stage scientific discovery.”

“This collaboration with LDC and the University of Leeds on metabolic projects is the first fruit of Arix’s partnership with the Lead Discovery Center and Max Planck Innovation GmbH, which demonstrates our ability to convert our high-quality relationships into tangible projects based on academic scientific excellence with long-term commercial potential.”

For more information, please contact:

Arix Bioscience PLC
Joe Anderson, CEO
+44 (0) 20 7290 1052

Consilium Strategic Communications
Mary-Jane Elliott, Jessica Hodgson, Ivar Milligan
+44 (0)20 3709 5700
arix@consilium-comms.com

About Arix Bioscience plc
Arix Bioscience plc is a global healthcare and life science company supporting medical innovation. Headquartered in London and with an office in New York, Arix Bioscience sources, finances and builds world class healthcare and life science businesses addressing medical innovation at all stages of development. Operations are supported by privileged access to breakthrough academic science and strategic relationships with leading research accelerators and global pharmaceutical companies.
Arix Bioscience plc is listed on the Main Market of the London Stock Exchange.
For further information, please visit www.arixbioscience.com

About the University of Leeds
The University of Leeds has a long-standing history of working with entrepreneurs and venture firms to take innovative technologies discovered within its academic faculties through into commercialisation. The University has a strong track record in commercialisation with over 100 spin-out companies created since 1995 – the second highest number of any UK university – including 34 currently active and seven of which are market listed.