Scientific Journals and Books

2026

Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1

Krings K S, Hatzfeld J, Weller S, Borkowski N, Llewellyn T R, Schmitt L, Scherer B, Itkonen H M, Peter C, Stork B, Geyh S, Eickhoff J, Klebl B, Qin N, Essmann F and Wesselborg S. Cell Death Dis. 2026; 17 (1): doi: 10.1038/s41419-026-08889-6

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor alpha-Hemolysin by Blocking the Pullout of Its Stem Domain

Korotkov V S, Lukat P, Di Lucrezia R, Shekhar A, Degenhart C, Diestel R, Bilitewski U, Dinkel K, Blankenfeldt W and Bronstrup M. ChemMedChem. 2026; 21 (4): e202501098. doi: 10.1002/cmdc.202501098

Reducing PI4KIIIalpha Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical Neurons

Clemente E, Sivasubramanian R, Kordes S, Bhatia P, Hans R, Vogel S, Baumann M, Klebl B and Sterneckert J. Cells. 2026; 15 (13): doi: 10.3390/cells15131228

Towards selective peptide deformylase inhibitors: A mass spectrometry-based evaluation of in cellulo activity of actinonin and bromoindole derivatives

Bachmann N, Schultz A, Zouatom M, Zhou T, Degenhart C, Koch U, Schakermann S, Huning J, Heinrich S, Dal Molin M, Zischinsky M L, Tourel S, Klebl A K, Rybniker J, Klebl B M, Scherkenbeck J and Bandow J E. Eur J Med Chem. 2026; 308 118678. doi: 10.1016/j.ejmech.2026.118678

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics

Al Kabbani M A, Jatoo P, Klebl A K, Klebl B and Zempel H. PLoS One. 2026; 21 (3): e0339922. doi: 10.1371/journal.pone.0339922

2022

Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice

Beamer E, Morgan J, Alves M, Menendez Mendez A, Morris G, Zimmer B, Conte G, de Diego-Garcia L, Alarcon-Vila C, Yiu Ng N K, Madden S, Calzaferri F, de Los Rios C, Garcia A G, Hamacher M, Dinkel K, Pelegrin P, Henshall D C, Nicke A, Engel T. Br J Pharmacol. 2022; 179 (12): 2986-3006. doi: 10.1111/bph.15785

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

Kaufmann J, Blum N K, Nagel F, Schuler A, Drube J, Degenhart C, Engel J, Eickhoff J E, Dasgupta P, Fritzwanker S, Guastadisegni M, Schulte C, Miess-Tanneberg E, Maric H M, Spetea M, Kliewer A, Baumann M, Klebl B, Reinscheid R K, Hoffmann C, Schulz S. Commun Biol. 2022; 5 (1): 1206. doi: 10.1038/s42003-022-04135-9

A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling

Bruggenthies J B, Fiore A, Russier M, Bitsina C, Brotzmann J, Kordes S, Menninger S, Wolf A, Conti E, Eickhoff J E, Murray P J. J Biol Chem. 2022; 298 (12): 102629. doi: 10.1016/j.jbc.2022.102629

OCT4 interprets and enhances nucleosome flexibility

MacCarthy C M, Huertas J, Ortmeier C, Vom Bruch H, Tan D S, Reinke D, Sander A, Bergbrede T, Jauch R, Scholer H R, Cojocaru V. Nucleic Acids Res. 2022; 50 (18): 10311-10327. doi: 10.1093/nar/gkac755

White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy

Dahl E, Villwock S, Habenberger P, Choidas A, Rose M, Klebl B M. Cancers (Basel). 2022; 14 (18): doi: 10.3390/cancers14184386

Synthesis, Biological Evaluation, and Binding Mode of a New Class of Oncogenic K-Ras4b Inhibitors

Jeuken S, Shkura O, Roger M, Brickau V, Choidas A, Degenhart C, Gulden D, Klebl B, Koch U, Stoll R, Scherkenbeck J. ChemMedChem. 2022; 17 (22): e202200392. doi: 10.1002/cmdc.202200392

Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells

Armijo M E, Escalona E, Pena D, Farias A, Morin V, Baumann M, Klebl B M, Pincheira R, Castro A F. Front Pharmacol. 2022; 13 912688. doi: 10.3389/fphar.2022.912688

Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors

Lategahn J, Tumbrink H L, Schultz-Fademrecht C, Heimsoeth A, Werr L, Niggenaber J, Keul M, Parmaksiz F, Baumann M, Menninger S, Zent E, Landel I, Weisner J, Jeyakumar K, Heyden L, Russ N, Muller F, Lorenz C, Bragelmann J, Spille I, Grabe T, Muller M P, Heuckmann J M, Klebl B M, Nussbaumer P, Sos M L, Rauh D. J Med Chem. 2022; 65 (9): 6643-6655. doi: 10.1021/acs.jmedchem.1c02080

The Pseudo-Natural Product Rhonin Targets RHOGDI

Akbarzadeh M, Flegel J, Patil S, Shang E, Narayan R, Buchholzer M, Kazemein Jasemi N S, Grigalunas M, Krzyzanowski A, Abegg D, Shuster A, Potowski M, Karatas H, Karageorgis G, Mosaddeghzadeh N, Zischinsky M L, Merten C, Golz C, Brieger L, Strohmann C, Antonchick A P, Janning P, Adibekian A, Goody R S, Ahmadian M R, Ziegler S, Waldmann H. Angew Chem Int Ed Engl. 2022; 61 (18): e202115193. doi: 10.1002/anie.202115193

IMI European Lead Factory – democratizing access to high-throughput screening

Jones P S, Boucharens S, McElroy S P, Morrison A, Honarnejad S, van Boeckel S, van den Hurk H, Basting D, Huser J, Jaroch S, Ottow E, Benningshof J, Folmer R H A, Leemhuis F, Kramer-Verhulst P M, Nies V J M, Orrling K M, Rijnders T, Pfander C, Engkvist O, Pairaudeau G, Simpson P B, Ortholand J Y, Roche D, Domling A, Kuhnert S M, Roevens P W M, van Vlijmen H, van Wanrooij E J A, Verbruggen C, Nussbaumer P, Ovaa H, van der Stelt M, Simonsen K B, Tagmose L, Waldmann H, Duffy J, Finsinger D, Jurzak M, Burgess-Brown N A, Lee W H, Rutjes F, Haag H, Kallus C, Mors H, Dorval T, Lesur B, Ramon Olayo F, Hamza D, Jones G, Pearce C, Piechot A, Tzalis D, Clausen M H, Davis J, Derouane D, Vermeiren C, Kaiser M, Stockman R A, Barrault D V, Pannifer A D, Swedlow J R, Nelson A S, Orru R V A, Ruijter E, van Helden S P, Li V M, Vries T, de Vlieger J S B. Nat Rev Drug Discov. 2022; 21 (4): 245-246. doi: 10.1038/d41573-021-00196-3

Highly Accurate Filters to Flag Frequent Hitters in AlphaScreen Assays by Suggesting their Mechanism

Ghosh D, Koch U, Hadian K, Sattler M, Tetko I V. Mol Inform. 2022; 41 (3): e2100151. doi: 10.1002/minf.202100151

Yes, we use cookies,

Scientific Journals and Books

Archive