2015
Selective inhibitors of the FK506-binding protein 51 by induced fitGaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas A S, Draenert R, Binder E B, Almeida O F, Ruhter G, Uhr M, Schmidt M V, Touma C, Bracher A, Hausch F. Nat Chem Biol. 2015; 11 (1): 33-37. doi: 10.1038/nchembio.1699
Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like librarisCraven P, Aimon A, Dow M, Fleury-Bregeot N, Guilleux R, Morgentin R, Roche D, Kalliokoski T, Foster R, Marsden S P, Nelson A. Bioorg Med Chem. 2015; 23 (11): 2629-2635. doi: 10.1016/j.bmc.2014.12.048
Medicinal Chemists of the 21st Century – Who Are We and Where to Go?Nussbaumer P. ChemMedChem. 2015; 10 (7): 1133-1139. doi: 10.1002/cmdc.201500133
Expansion of Chemical Space for Collaborative Lead Generation and Drug Discovery: The European Lead Factory PerspectiveKarawajczyk A, Giordanetto F, Benningshof J, Hamza D, Kalliokoski T, Pouwer K, Morgentin R, Nelson A, Muller G, Piechot A, Tzalis D. Drug Discov Today. 2015; 20 (11): 1310-1316. doi: 10.1016/j.drudis.2015.09.009
Professional translational research: a new hybrid paradigm in early drug discoveryNussbaumer P, Klebl B. Future Med Chem. 2015; 7 (14): 1879-1889. doi: 10.4155/fmc.15.124
Price-Focused Analysis of Commercially Available Building Blocks for Combinatorial Library SynthesisKalliokoski T. ACS Comb Sci. 2015; 17 (10): 600-607. doi: 10.1021/acscombsci.5b00063
Protein-protein interactions as drug targetsSkwarczynska M, Ottmann C. Future Med Chem. 2015; 7 (16): 2195-2219. doi: 10.4155/fmc.15.138
Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule librariesColomer I, Adeniji O, Burslem G M, Craven P, Rasmussen M O, Willaume A, Kalliokoski T, Foster R, Marsden S P, Nelson A. Bioorg Med Chem. 2015; 23 (11): 2736-2740. doi: 10.1016/j.bmc.2015.01.058
A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar ConcentrationsHutterer C, Eickhoff J, Milbradt J, Korn K, Zeittrager I, Bahsi H, Wagner S, Zischinsky G, Wolf A, Degenhart C, Unger A, Baumann M, Klebl B, Marschall M. Antimicrob Agents Chemother. 2015; 59 (4): 2062-2071. doi: 10.1128/AAC.04534-14